miRNA在高磷诱导的血管钙化中的作用

The role of microRNA in high phosphorus induced vascular calcification

血管钙化是慢性肾脏病患者心血管疾病发生及发展的病理基础。高磷血症是导致慢性肾脏病患者发生血管钙化的最主要危险因素。在高磷状态下,微小RNA(microRNA,miRNA)通过转录后负性调控靶细胞表达促进或抑制钙化因子而起到调控血管钙化的作用。因此,鉴定高磷状态下miRNA的异常产生有助于识别表观遗传变化,这些变化可以作为预防和治疗高磷血症诱导的血管钙化的靶点。现综述目前发现的与高磷诱导血管钙化发生有关的miRNA及其作用机制。

Vascular calcification is the pathological basis of the occurrence and development of cardiovascular disease in patients with chronic kidney disease.Hyperphosphatemia is the most important risk factor for vascular calcification in patients with chronic kidney disease.It has been found that under high phosphorus conditions,microRNA(miRNA)plays a role in regulating vascular calcification by negatively regulating the expression of target cells after transcription to promote or inhibit calcification factors.Therefore,identifying the abnormal production of miRNA under hyperphosphatemia is helpful to identify epigenetic changes,which can be used as a target for the prevention and treatment of hyperphosphatemia induced vascular calcification.In this review,miRNA and their mechanisms related to high phosphate induced vascular calcification are reviewed.