斯钙素2在喉癌组织中的表达水平及其对患者术后辅助放疗预后的预测价值

Expression of stanniocalcin 2 in laryngeal carcinoma tissues and its predictive value on patients′prognosis of postoperative adjuvant radiotherapy

目的探讨斯钙素2(STC2)在喉癌组织中的表达水平及其对患者术后辅助放疗预后的预测价值。方法选取90例行术后辅助放疗的喉癌患者作为研究对象,采用免疫组织化学法检测喉癌组织和癌旁正常组织的STC2阳性表达率。根据喉癌组织中STC2的表达水平将患者分为STC2阳性表达组(n=54)和STC2阴性表达组(n=36),比较两组患者的无病生存期。比较不同特征患者喉癌组织STC2阳性表达率。采用受试者工作特征曲线评价STC2阳性表达对患者术后辅助放疗预后的预测价值。结果喉癌组织中STC2阳性表达率高于癌旁正常组织(P<0.05)。不同临床分期、分化程度、术后3年内淋巴结转移情况、术后3年内复发情况的患者之间喉癌组织中STC2阳性表达率差异均有统计学意义(均P<0.05)。STC2阳性表达组的中位无病生存期短于STC2阴性表达组(P<0.05)。STC2阳性表达预测患者术后辅助放疗预后的敏感度和特异度分别为88.30%、80.00%,曲线下面积为0.915。结论STC2在喉癌组织中的阳性表达率高于癌旁正常组织,且与喉癌患者术后辅助放疗预后有关,或可作为喉癌患者术后辅助放疗预后的预测因子。

Objective To investigate the expression of stanniocalcin 2(STC2)in laryngeal carcinoma tissues and its predictive value on patients′prognosis of postoperative adjuvant radiotherapy.Methods A total of 90 patients with laryngeal carcinoma undergoing postoperative adjuvant radiotherapy were selected as the research subjects.The positive expression rates of STC2 in laryngeal cancerous tissues and paracancerous normal tissues were detected by the immunohistochemistry.The patients were assigned to the STC2 positive expression group(n=54)or the STC2 negative expression group(n=36)according to STC2 expression in laryngeal cancerous tissues.The disease-free survival was compared between the two groups.The positive expression rate of STC2 in laryngeal cancerous tissues was compared between the patients with different features.The predictive value of STC2 positive expression on patients′prognosis of postoperative adjuvant radiotherapy was evaluated by the receiver operating characteristic curve.Results The positive expression rate of STC2 in laryngeal cancerous tissues was higher than that in paracancerous normal tissues(P<0.05).There was statistically significant difference in the STC2 positive expression rate of laryngeal cancerous tissues between the patients with different clinical stages,differentiated degrees,metastasis conditions of lymph nodes within 3 years after operation,and recurrence conditions within 3 years after operation(all P<0.05).The STC2 positive expression group exhibited a shorter median disease-free survival as compared with the STC2 negative expression group(P<0.05).The sensitivity and specificity of STC2 positive expression in predicting the patients′prognosis of postoperative adjuvant radiotherapy were 88.30%and 80.00%,respectively,and the area under the curve was 0.915.Conclusion The STC2 positive expression rate in laryngeal cancerous tissues is higher than that in paracancerous normal tissues,and it is related to the prognosis of postoperative adjuvant radiotherapy in patients with laryngeal carcinoma,which may be used as a predictor for the prognosis of postoperative adjuvant radiotherapy in patients with laryngeal carcinoma.