髓核间充质干细胞在椎间盘退变修复中的研究进展

Research progress on the repair of intervertebral disc degeneration with nucleus pulposus-derived mesenchymal stem cell

间充质干细胞是一种具有自我更新和多向分化能力的多能干细胞。髓核间充质干细胞(NPMSC)作为椎间盘源性的间充质干细胞,在适应椎间盘退变(IDD)后的酸性、低氧、高渗、异常压应力及营养缺乏恶劣微环境中有着天然优势,其可以通过移植、内源性激活及自身的迁移和募集来修复IDD。分析表明,NPMSC在IDD的内源性修复中有着巨大潜力。本文回顾近年来基于NPMSC的IDD修复策略作一综述,以期进一步明确未来研究方向,为寻求IDD的可靠治疗方法提供思路。

Mesenchymal stem cells are pluripotent stem cells with self-renewal and multi-directional differentiation capabilities.Nucleus pulposus-derived mesenchymal stem cell(NPMSC),as intervertebral disc-derived mesenchymal stem cell,has a natural advantage in adapting to the harsh microenvironment of acidity,hypoxia,hyperosmolar,abnormal compressive stress and nutritional deficiency after intervertebral disc degeneration(IDD)and can repair IDD through transplantation,endogenous activation and its own migration and recruitment.The analysis has shown that NPMSC has great potential in the endogenous repair of IDD.This paper reviews the repair strategies of IDD based on NPMSC in recent years,in order to further clarify the future research direction and provide ideas for seeking reliable treatment methods of IDD.