绝经后妇女宫颈HPV感染及宫颈病变的临床治疗探讨

Clinical treatment of cervical HPV infection and cervical lesions in postmenopausal women

目的 探讨绝经后宫颈人乳头瘤病毒(HPV)感染及宫颈病变患者的临床治疗方案。方法 选取绝经后宫颈HPV感染及宫颈病变患者72例作为研究对象,按照随机数字表法将其分为对照组和研究组,各36例。对照组采用高能聚焦超声疗法,研究组采用利普刀疗法,两组均观察至术后12个月。比较两组术后3个月临床疗效,病毒滴度水平及HPV转阴率。结果 术后6个月,研究组临床总有效率(97.22%)高于对照组(72.20%);与术前比,术后3个月、术后6个月两组病毒滴度水平呈逐渐降低趋势,其中研究组低于对照组;术后3个月、术后6个月、术后12个月两组HPV转阴率呈逐渐升高趋势,其中研究组高于对照组,差异有统计学意义(P<0.05)。结论 在对绝经后宫颈HPV感染及宫颈病变患者进行治疗时,使用利普刀疗法能够有效降低患者病毒滴度水平,提高临床疗效,促进HPV转阴,应用效果显著。

Objective To explore the clinical treatment plan of postmenopausal patients with cervical human papillomavirus(HPV) infection and cervical lesions. Methods A total of 72 postmenopausal patients with cervical HPV infection and cervical lesions were selected as the research subjects, and they were divided into the control group and the research group according to the random number table method, with 36 cases in each group. The control group was treated with high-energy focused ultrasound therapy, and the research group was treated with lip knife therapy. Both groups were observed until 12 months after operation.The clinical efficacy, virus titer level and HPV negative rate were compared between the two groups at 3 months after operation.Results At 6 months after operation, the total clinical effective rate(97.22%) of the research group was higher than that of the control group(72.20%);compared with before operation, the virus titer levels of the two groups at 3 months and 6 months after operation showed a decreasing trend, the research group was lower than the control group;the HPV negative conversion rate at 3 months after operation, 6 months after operation, and 12 months after operation showed a gradually increasing trend, among which the research group was higher than the control group, and the difference was statistically significant significance(P<0.05).Conclusion In the treatment of postmenopausal women with cervical HPV infection and cervical lesions, the use of lip knife therapy can effectively reduce the patient’s titer level, improve clinical efficacy, promote HPV negative conversion, and improve patients’ quality of life. The application effect is remarkable.