可调谐光流控装置实现微粒筛选与存储研究

Study of Tunable Optofluidic Device for Particle Sorting and Storing

基于在波导旁边的微环谐振和耦合波导对处倏逝波的光捕获能力,提出了一种由硫族化合物半导体SbSe组成的光流控装置,可以通过SbSe在非晶态和结晶态之间的相变对装置所实现的功能进行主动调制,使装置能够在单波长输入条件下,实现两种不同的工作状态。采用球形和棒状聚苯乙烯颗粒作为模型系统,其中球形(直径为0.5μm)和棒状(直径为0.5μm,长度为1.5μm)的聚苯乙烯颗粒可以分别模拟金黄色葡萄球菌和杆状大肠杆菌这两种不同的细菌用于实现该装置的形状筛选功能。通过加热SbSe到结晶温度(T=200℃),使波导和谐振环的材料相变,可以调节装置在存储微纳米粒子、筛选微纳米粒子两种功能之间切换。这可能会为生物分子的形状选择性筛分提供参考,满足新一代芯片实验室技术的要求。

Based on the evanescent waves of microring resonance next to the waveguide and the bus waveguide,an optofluidic device composed of the chalcogenide semiconductor SbSewas proposed.The function of device could be actively modulated by the phase change of SbSe,so that the device could realize two different functions under the condition of single wavelength input.Spherical and rod-shaped polystyrene particles were used as model systems,in which spherical(0.5μm in diameter)and rod-shaped(0.5μm in diameter and 1.5μm in length)polystyrene particles could simulate Staphylococcus aureus and rod-shaped Escherichia coli,respectively.These two different bacteria were used to implement the shape-sorting function of the device.By heating SbSeto the crystallization temperature(T=200℃),the materials of the waveguide and the resonant ring were phasetransformed,and the device could be tuned to switch between the two functions of storing particles and sorting particles.The protocol may provide a reference for shape-selective screening of biomolecules and meet the requirements of a new generation of lab-on-a-chip technology.