摘要
胰腺癌发病率和死亡率在全球范围呈上升趋势,其诊治及预后具有重要意义。神经调节蛋白1(NRG1)基因位于8号染色体8p12区,编码NRG1,NRG1含有一个表皮生长因子(EGF)样结构域,该结构域与ERBB/HER受体组的人酪氨酸激酶结合,特别是ERBB3和ERBB4,从而激活ERBB介导的下游信号通路,从而转化为细胞生长。但其表达异常时可能导致肿瘤的发生。NRG1对胰腺癌有肿瘤促进作用,现就NRG1及其在胰腺癌中作用以及相关研究进行描述,结合其在肿瘤发生、发展等多方面因素进行讨论,为进一步研究及其临床应用提供参考。
The incidence rate and mortality of pancreatic cancer are on the rise globally,its diagnosis,treatment and prognosis are of great significance.The neuregulin 1(NRG1)gene is located in the 8p12 region of chromosome 8,which encodes NRG1.NRG1 contains an epidermal growth factor(EGF)-like domain,which is closely related to the ERBB/HER receptor group.Binds to human tyrosine kinases,especially ERBB3 and ERBB4,thereby activating ERBB-mediated downstream signaling pathways that translate into cell growth.But its abnormal expression may lead to tumorigenesis.NRG1 plays a tumor-promoting role in pancreatic cancer.Now NRG1 and its role in pancreatic cancer and related research are described,combined with its various factors such as tumor occurrence and development,and are discussed for further research and its related research,to provide reference for clinical application.
作者
贾雅茹
赵海平
王飞
JIA Ya-ru;ZHAO Hai-ping;WANG Fei(Department of Hepatobiliary Pancreatic Splenic Surgery,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia 015000,China)
出处
《中国临床研究》
CAS
2022年第11期1578-1581,共4页
Chinese Journal of Clinical Research
基金
内蒙古自治区卫生健康科技项目(202201331)
内蒙古自治区高等学校科学研究项目(NJZZ22651)。
