胆道闭锁患儿Kasai手术年龄选择与预后关系的研究进展

Research advances on the relationship between age at Kasai portoenterostomy and prognosis for biliary atresia

Kasai手术是胆道闭锁的首选治疗方法,手术年龄是影响患儿预后、避免肝移植的重要因素。选择合适手术年龄、解除胆道梗阻恢复胆汁引流、提高自体肝生存时间、避免过早行肝移植是临床医师共同努力的方向。Kasai手术年龄与黄疸清除率、自体肝生存率及术后胆管炎发生率均存在相关性。本文系统综述了胆道闭锁Kasai手术年龄选择的相关研究进展,旨在为探索最佳Kasai手术年龄提供参考。

Kasai portoenterostomy is the preferred treatment for biliary atresia.Age at Kasai portoenterostomy is an important factor affecting the prognosis of children with biliary atresia and avoiding liver transplantation.Choosing the appropriate surgical age,restoring good bile drainage,improving the native liver survival rate,and avoiding early liver transplantation are the items that clinicians have always been working on.The age at Kasai portoenterostomy was correlated with the jaundice clearance rate,native liver survival rate,and the incidence of postoperative cholangitis.This article systematically reviewed the research advances on the relationship between age at Kasai portoenterostomy and prognosis for biliary atresia,aiming to provide the basis for the ideal surgical age of Kasai.