胃血清学活检在胃溃疡诊断中的应用

Application of Gastric Serological Biopsy in the Diagnosis of Gastric Ulcer

目的:分析胃血清学活检在胃溃疡诊断与治疗中的应用价值。方法:选取广州市番禺区中心医院2020年11月至2021年12月收治的50例因胃部不适的初诊患者,经胃镜活检,病理确诊为胃溃疡,另选100例健康体检人群为体检组。所有研究对象均采用化学发光法检测血清胃蛋白酶原(PG)Ⅰ、PGⅡ、胃泌素17(G-17),并计算PGⅠ/PGⅡ比值(PGR),比较两组的检测结果。结果:胃溃疡组的PGⅠ、PGⅡ,PGR以及G-17水平均明显高于体检组,差异具有统计学意义(P<0.05);受试者工作特征曲线(ROC)分析结果显示,血清PGⅠ、PGⅡ、PGR、G-17诊断胃溃疡的曲线下面积(AUC)分别为0.898、0.807、0.724、0.856,最佳临界值分别为191.6μg·L^(-1)、16.25μg·L^(-1)、11.21、6.70 pmol·L^(-1)。PGⅠ、PGⅡ、PGR、G-17四项联合检测灵敏度和特异度分别为86.0%和97.0%。结论:PGⅠ、PGⅡ、PGR、G-17水平升高,提示患有胃溃疡风险增高。

Objective To analyze the application value of gastric serological biopsy in the diagnosis and treatment of gastric ulcer.Methods A total of 50 newly diagnosed patients with stomach discomfort admitted to Guangzhou Panyu Central Hospital from November 2020 to December 2021 were selected,who were pathologically confirmed as gastric ulcer by gastroscopic biopsy,and another 100 physical examination healthy people were selected as the physical examination group.The serum pepsinogen(PG)Ⅰ,PGⅡand gastrin 17(G-17)were detected by chemiluminescence method,and the ratio of PGⅠ/PGⅡ(PGR)was calculated,and the detection results of the two groups were compared.Results The levels of PGⅠ,PGⅡ,PGR and G-17 in the gastric ulcer group were significantly higher than those in the physical examination group(P<0.05).The results of receiver operating characteristic curve(ROC)analysis showed that the area under curve(AUC)of serum PGⅠ,PGⅡ,PGR,G-17 in the diagnosis of gastric ulcer were 0.898,0.807,0.724,0.856,respectively.The optimal critical values were 191.6μg·L^(-1),16.25μg·L^(-1),11.21,6.70 pmol·L^(-1),respectively.The sensitivity and specificity of the combined detection of PGⅠ,PGⅡ,PGR and G-17 were 86.0%and 97.0%,respectively.Conclusion The increased levels of PGⅠ,PGⅡ,PGR and G-17 indicate an increased risk of gastric ulcer.