新生儿低血糖与脑易损性的相关性研究

Study on the Correlation Between Neonatal Hypoglycemia and Brain Vulnerability

目的评价新生儿低血糖与脑易损性的相关性。方法选择100例我院收治的新生儿低血糖症患儿,通过脑部MRI检查,根据其是否有脑部损伤将100患儿分为脑损伤组(n=34)和无脑损伤组(n=66)组。对比分析两组患儿血糖水平、低血糖的持续时间、首次诊断的时间以及血清学指标,采用Pearson相关法分析新生儿低血糖与脑易损性的相关性。结果两组新生儿血糖水平首次诊断的时间比较,差异无统计学意义(P>0.05);脑损伤组新生儿血糖水平显著低于无脑损伤组,而低血糖的持续时间、脐带血GFAP、MBP、NSE和S100水平则显著高于无脑损伤组,差异有统计学意义(P<0.05)。相关性结果表明,新生儿低血糖与脑易损性存在显著的正相关关系(P<0.05)。结论新生儿低血糖与脑易损性存在显著的正相关关系。及时监测新生儿的血糖,有利于提升新生儿低血糖性脑损伤的临床治疗效果。

Objective To evaluate the correlation between neonatal hypoglycemia and brain vulnerability.Methods A total of 100 neonates with hypoglycemia admitted to our hospital were divided into brain injury group(n=34)and no brain injury group(n=66)according to brain MRI examination.Blood glucose level,duration of hypoglycemia,time of first diagnosis and serological indexes of the two groups were compared and analyzed.Pearson correlation method was used to analyze the correlation between neonatal hypoglycemia and brain vulnerability.Results There was no significant difference in the time of first diagnosis of blood glucose between the two groups(P>0.05).The neonatal blood glucose level in the brain injury group was significantly lower than that in the non-brain injury group,while the duration of hypoglycemia and the levels of CORD blood GFAP,MBP,NSE and S100 were significantly higher than those in the non-brain injury group,the differences were statistically significant(P<0.05).Correlation results showed that there was a significant positive correlation between neonatal hypoglycemia and brain vulnerability(P<0.05).Conclusion There is significant positive correlation between neonatal hypoglycemia and brain vulnerability.Timely monitoring of neonatal blood glucose is beneficial to improve the clinical treatment effect of neonatal hypoglycemic brain injury.