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肠道菌群与肌少症发生机制及其临床意义的研究进展 被引量:4

Influence of intestinal flora on the mechanism of sarcopenia and its clinical significance:research progress
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摘要 肠道菌群是一个复杂的微生物群落,其变化不仅与各种肠道疾病相关,而且还与衰老性疾病(如肌少症)密切相关。肌少症是一种与年龄有关的骨骼肌质量、力量和体力丧失的综合征。到目前为止,肌少症的发病机制尚不清楚。近年来,越来越多的证据表明肠道菌群通过其代谢产物来影响骨骼肌的动态平衡,这被认为是肌少症发生的可能的生物学基础。本文就肠道菌群与肌少症关系的研究进展作一综述,探讨肠道菌群在肌少症发生发展中的可能作用机制,并展望肠道菌群在临床预防和治疗肌少症中的作用。 Intestinal flora is a complex microbial community. Its changes affect not only various intestinal diseases, but also aging diseases, such as sarcopenia. Sarcopenia is a syndrome of age-related loss of skeletal muscle mass, strength and physical strength. So far, the pathogenesis of sarcopenia still remains unknown. In recent years, more and more evidences have shown that the intestinal flora affects the dynamic balance of skeletal muscle through its metabolites, which is considered to be a possible biological basis for the onset of sarcopenia. This article focuses on the progress in research on the relationship between the intestinal flora and sarcopenia, discusses the possible role of the intestinal flora in the occurrence and development of sarcopenia, and prospects its role in the prevention and treatment of sarcopenia.
作者 王晓婷 迟鸿堃 王阳 张伟 WANG Xiao-ting;CHI Hong-kun;WANG Yang;ZHANG Wei(Geriatrics Department,Dalian Friendship Hospital,Dalian,Liaoning 116100,China;不详)
出处 《中国微生态学杂志》 CAS CSCD 2022年第9期1107-1111,1116,共6页 Chinese Journal of Microecology
关键词 肌少症 肠道菌群 衰老性疾病 肠-肌轴 Sarcopenia Intestinal flora Aging disease Gut-muscle axis
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