环状RNA作为脑肿瘤潜在生物学标志物的研究进展

Research Progress on Circular RNA as a Potential Biomarker of Brain Tumors

环状RNA(circular RNA,circRNA)是一类无游离5′端和3′端的共价闭合的非编码RNA,具有丰富性、稳定性、保守性和组织特异性等结构特点,circRNA与细胞增殖、凋亡、血管生成和转移等方面都有着密不可分的联系。脑肿瘤因为其独特的微环境造成了其发生发展机制的特殊性。研究circRNA与脑肿瘤发生发展的机制,必将促进对脑肿瘤诊断、治疗预后等多方面的发展。全文综述circRNA在常见脑肿瘤(胶质瘤、垂体瘤和髓母细胞瘤)中的表达情况及其靶向miRNA和后续信号通路,并概述其作用结果,总结circRNA作为多种脑肿瘤的潜在生物学标志物。

Circular RNA(circRNA)is a class of covalently closed non-coding RNA that without 5′cap and 3′poly A tail.They have the characteristics such as richness,stability,high conservatism and tissue specificity.With the in-depth study of the mechanism of circRNA in tumorigenesis and development,we found that circRNA is closely related to cell proliferation,apoptosis,angiogenesis and metastasis.Brain tumors have the specific mechanism of tumorigenesis and development because of their unique microenvironment.The study of the mechanism of circRNA with the tumorigenesis and development of brain tumors will promote the progress of diagnosis,treatment and prognosis of brain tumors.This article reviews the expression of circRNA in some common brain tumors(such as glioma,pituitary adenoma and medulloblastoma)and their targeting miRNA and related signal pathways,and summarizes the functions of circRNA in the tumors.Finally we concludes that circRNA may act as potential biomarkers for commom brain tumors.