摘要
慢性萎缩性胃炎(CAG),以及在此基础上发生的胃黏膜肠上皮化生(GIM)使胃癌发生风险显著升高,阻断胃黏膜萎缩和GIM的发展对于降低胃癌发病率具有重要意义。既往研究认为,根除幽门螺杆菌可在一定程度上逆转胃黏膜萎缩。新近研究发现,GIM也可在一定程度上被逆转。临床研究表明,羔羊胃提取物维B12对GIM具有显著的逆转效应。本文就CAG诊疗和羔羊胃提取物维B12临床应用进行综述,并制定专家指导意见,以更好地指导CAG和GIM的逆转治疗。
Chronic atrophic gastritis(CAG)and gastric intestinal metaplasia(GIM)significantly increase the risk of gastric cancer.Blocking the development of CAG and GIM would help to decrease the incidence of gastric cancer.It was revealed that eradication of Helicobacter pylori could reverse gastric mucosa atrophy.Recent studies reported that GIM could be reversed to a certain extent.Clinical studies demonstrated that Lamb′s tripe extract and vitamin B12 capsule exhibited significant reversal effects on GIM.The present study systemically reviewed the diagnosis and treatment of CAG and clinical application of Lamb′s tripe extract and vitamin B12 capsule,and established the specialist instruction that would guide the reversal treatment of CAG and GIM.
作者
时永全
陈敏
王学红
郑勇
曲波
张晓岚
杨仕明
吴开春
Shi Yongquan;Chen Min;Wang Xuehong;Zheng Yong;Qu Bo;Zhang Xiaolan;Yang Shiming;Wu Kaichun(National Clinical Research Center for Digestive Diseases,State Key Laboratory of Cancer Biology,Department of Gastroenterology,First Affiliated Hospital,Air Force Medical University,Xi′an 710032,China;Department of Gastroenterology,the Hospital Affiliated to Qinghai University,Xining 810000,China;Department of Gastroenterology,First Affiliated Hospital,School of Medicine,Shihezi University,Shihezi 832008,China;Department of Gastroenterology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Department of Gastroenterology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Department of Gastroenterology,Second Affiliated Hospital,Land Force Medical University,Chongqing 400037,China)
出处
《中华消化杂志》
CAS
CSCD
北大核心
2022年第9期577-584,共8页
Chinese Journal of Digestion
关键词
慢性萎缩性胃炎
肠上皮化生
羔羊胃提取物维B12
幽门螺杆菌
Chronic atrophic gastritis
Intestinal metaplasia
Lamb′s tripe extract and vitamin B12 capsule
Helicobacter pylori
