性别差异对循环系统常见慢性疾病药物治疗的影响研究进展

Research progress in influence of gender difference on drug therapy of common chronic diseases of the cardiovascular system

性别差异导致了疾病的发病机制、药代动力学、药效学及药物治疗方案等方面的不同,对于疾病的预防及治疗具有重要意义。循环系统疾病是21世纪威胁人类健康的重大卫生问题。本文检索2010年1月1日至2021年4月5日中国知网、万方数据、维普网、PubMed、Web of Sciencey数据库发表的相关文献,从疾病发生机制、药物的药代动力学及药效学、药物治疗效果、药品不良反应发生率等方面对循环系统常见慢性疾病(包括高血压病、慢性心功能不全、冠状动脉粥样硬化性心脏病及心房颤动)药物治疗的性别差异进行综述,以期为临床个体化用药提供参考,促进合理用药。

Gender-related differences can make a difference to pathogenesis,pharmacokinetics,pharmacodynamics and drug treatment regimens,which is of great significance for prevention and treatment of diseases.Diseases of the circulatory system have become a major health issue that poses a threat to human health in the 21st century.Such databases as CNKI,Wangfang,VIP,PubMed and Web of Science were searched from January 1,2010 to April 5,2021.Gender differences in pharmacotherapy of common chronic diseases of the circulatory system(hypertension,chronic cardiac insufficiency,coronary heart disease and atrial fibrillation)were outlined in terms of pathogenesis,pharmacokinetics,pharmacodynamics,efficacy and the incidence of adverse reactions in order to provide reference for individualized medications and promote rational drug use.