熊去氧胆酸的临床应用进展

Clinical application of ursodeoxycholic acid

熊去氧胆酸(ursodeoxycholic acid,UDCA)是由胆固醇衍生而来的天然亲水性胆汁酸,可通过抑制胆固醇在肠道内的重吸收和降低胆固醇向胆汁中的分泌,从而降低胆固醇的饱和度,临床上主要用于胆石症、胆汁淤积性肝病、胆汁反流性胃炎、原发性硬化性胆管炎等的治疗。本文从UDCA临床应用和指南推荐角度,总结其在疾病的应用、不良反应和药学监护等,为UDCA的临床合理应用提供参考。

Ursodeoxycholic acid is a natural hydrophilic bile acid derived from cholesterol,which can inhibit the reabsorption of cholesterol in the intestine and reduce the secretion of cholesterol into bile.Thereby reducing the saturation of cholesterol,it is mainly used clinically for the treatment of cholelithiasis,cholestatic liver disease,bile reflux gastritis,primary sclerosing cholangitis,etc.This article summarizes the clinical application of ursodeoxycholic acid and the recommendations of the guidelines,summarizes its application in diseases,adverse reactions and pharmaceutical monitoring,etc.,and provides a reference for the reasonable clinical application of ursodeoxycholic acid.