针刺疗法联合尼莫地平片治疗血管性痴呆临床研究

Clinical Study on Acupuncture Therapy Combined with Nimodipine Tablets for Vascular Dementia

目的:观察针刺疗法联合尼莫地平片治疗血管性痴呆的临床疗效。方法:选取90例血管性痴呆患者,按随机数字表法分为对照组及研究组各45例。对照组给予口服尼莫地平片治疗,研究组在对照组基础上加用针刺疗法。比较2组治疗前后血清超敏C-反应蛋白(hs-CRP)、精神状态[简易智力状态检查表(MMSE量表)]、智能状态[长谷川痴呆量表(HDS量表)]及日常生活能力量表(ADL量表)评分的变化。结果:治疗后,2组血清hs-CRP水平均较治疗前下降,研究组hs-CRP水平低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组MMSE评分、HDS评分均较治疗前升高,比较研究组MMSE评分、HDS评分均高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组ADL评分均较治疗前升高,研究组ADL评分高于对照组,差异均有统计学意义(P<0.05)。结论:针刺疗法联合尼莫地平片治疗血管性痴呆效果确切,能有效抑制炎性反应,改善患者认知功能,提高智力水平及日常生活能力。

Objective:To observe the clinical effect of acupuncture therapy combined with nimodipine tablets for vascular dementia. Methods: A total of 90 cases of patients with vascular dementia were selected and divided into the control group and the study group according to the random number table method, with 45 cases in each group. The control group was given oral administration of nimodipine tablets,and the study group was additionally treated with acupuncture therapy based on the treatment of the control group. Before and after treatment,the changes in high-sensitivity C-reactive protein(hs-CRP) in serum,mental state shown by Mini-Mental State Examination(MMSE),intellectual status by Hasegawa’s Dementia Scale(HDS) and scores of Activities of Daily Living Scale(ADL) in the two groups were compared.Results:After treatment,the hs-CRP levels in serum in the two groups were decreased when compared with those before treatment,and the hs-CRP level in the study group was lower than that in the control group,differences being significant(P<0.05). After treatment,the scores of MMSE and HDS in the two groups were increased when compared with those before treatment,and the scores of MMSE and HDS in the study group were higher than those in the control group,differences being significant(P<0.05). After treatment, the ADL scores in the two groups were increased when compared with those before treatment,and the ADL score in the study group was higher than that in the control group,differences being significant(P<0.05). Conclusion: Acupuncture therapy combined with nimodipine tablets has a definite effect in treating vascular dementia, and can effectively inhibit inflammatory responses, and improve cognitive function,intelligence levels and activities of daily living.