摘要
目的:观察知柏地黄汤联合醋酸亮丙瑞林微球治疗女童特发性中枢性性早熟的临床疗效及其对性激素、瘦素、脂联素水平的影响。方法:选取62例特发性中枢性性早熟女童,按照随机抽签法分为研究组和对照组各31例。对照组采用醋酸亮丙瑞林微球治疗,研究组采用知柏地黄汤联合醋酸亮丙瑞林微球治疗。治疗3个月后,比较2组临床疗效,以及治疗前后血清性激素[卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))]水平、第二性征发育指标及瘦素(LP)、脂联素(ADP)水平变化。结果:研究组总有效率为93.54%,对照组为64.51%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组FSH、LH、E_(2)水平比较,差异均无统计学意义(P>0.05);治疗后,2组FSH、LH、E_(2)水平均较治疗前明显降低(P<0.05),且研究组上述各项指标均低于对照组(P<0.05)。治疗前,2组子宫容积、卵泡直径、卵巢容积比较,差异均无统计学意义(P>0.05);治疗后,2组子宫容积、卵泡直径、卵巢容积均较治疗前明显减小(P<0.05),且研究组上述各项指标均小于对照组(P<0.05)。治疗前,2组血清LP、ADP水平比较,差异均无统计学意义(P>0.05)。治疗后,2组LP水平均较治疗前明显降低(P<0.05),ADP水平较治疗前明显升高(P<0.05);且研究组LP、ADP水平改善较对照组更显著(P<0.05)。结论:知柏地黄汤联合醋酸亮丙瑞林微球可有效调节特发性中枢性性早熟女童的性激素及LP、ADP水平,改善第二性征发育指标,临床疗效显著。
Objective:To observe the clinical effect of Zhibai Dihuang tang combined with leuprolide acetate microspheres for idiopathic central precocious puberty in girls and its effect on levels of sex hormones,leptin and adiponectin.Methods:A total of 62 cases of girls with idiopathic central precocious puberty were selected and divided into the study group and the control group according to the method of random sampling,with 31 cases in each group.The control group was treated with leuprolide acetate microspheres,and the study group was treated with Zhibai Dihuang tang combined with leuprolide acetate microspheres.After three-month treatment,the clinical effects in the two groups were compared.Before and after treatment,the changes in sex hormones in serum including follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E_(2)),and growth indexes of secondary sex character,as well as the levels of leptin(LP)and adiponectin(ADP)in the two groups were compared.Results:The total effective rate was 93.54%in the study group and 64.51%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of FSH,LH and E_(2) between the two groups(P>0.05).After treatment,the levels of FSH,LH and E_(2) in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the above levels in the study group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of uterine volume,follicular diameter and ovarian volume between the two groups(P>0.05).After treatment,the uterine volume,follicular diameter and ovarian volume in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the above indexes in the study group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of LP and ADP in serum between the two groups(P>0.05).After treatment,the LP levels in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the ADP levels were significantly increased(P<0.05);the improvement in levels of LP and ADP in the study group was more significant than that in the control group(P<0.05).Conclusion:Zhibai Dihuang tang combined with leuprolide acetate microspheres can effectively regulate the levels of sex hormones,leptin and adiponectin in girls with idiopathic central precocious puberty,and improve the growth indexes of secondary sex character with a significant clinical effect.
作者
黄懿
裘利英
李岚
HUANG Yi;QIU Liying;LI Lan
出处
《新中医》
CAS
2022年第20期11-14,共4页
New Chinese Medicine
关键词
女童特发性中枢性性早熟
知柏地黄汤
性激素
瘦素
脂联素
Girls with idiopathic central precocious puberty
Zhibai Dihuang tang
Sex hormones
Leptin
Adiponectin