丹参川芎嗪注射液联合抗凝溶栓治疗下肢骨折后深静脉血栓临床研究

Clinical Study on Danshen Chuanxiongqin Injection Combined with Anticoagulant and Thrombolysis for Deep Vein Thrombosis After Lower Limb Fracture

目的:观察丹参川芎嗪注射液联合抗凝溶栓治疗下肢骨折后深静脉血栓(DVT)的临床疗效。方法:对86例下肢骨折后DVT患者按照随机数字表法分为对照组和观察组各43例。对照组给予抗凝溶栓治疗,观察组在对照组的基础上联合丹参川芎嗪注射液治疗。2周为1个疗程,治疗2个疗程后,比较2组临床疗效,治疗前后凝血功能[活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)和纤维蛋白原(Fib)]、血清炎症因子[白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平以及不良反应。结果:观察组总有效率为95.34%,对照组为81.39%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组APTT、PT、Fib水平比较,差异无统计学意义(P>0.05)。治疗后,2组APTT、PT水平均较治疗前升高(P<0.05),Fib水平均较治疗前降低(P<0.05);且观察组APTT、PT水平明显高于对照组(P<0.05),Fib水平明显低于对照组(P<0.05)。治疗前,2组IL-1、IL-6、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,2组IL-1、IL-6、TNF-α水平均较治疗前降低(P<0.05),且观察组IL-1、IL-6、TNF-α水平均低于对照组(P<0.05)。观察组不良反应发生率为9.30%,对照组为6.97%,2组比较,差异无统计学意义(P>0.05)。结论:丹参川芎嗪注射液联合抗凝溶栓治疗下肢骨折后DVT效果显著,可改善患者凝血功能,降低炎症因子水平,且用药安全性良好。

Objective:To observe the clinical effect of the therapy of Danshen Chuanxiongqin injection combined with anticoagulant and thrombolysis on deep venous thrombosis(DVT)after lower limb fracture.Methods:A total of 86 cases of patients with DVT after lower limb fracture were divided into the control group and the observation group according to the random number table method,with 43 cases in each group.The control group was treated with anticoagulant and thrombolysis,and the observation group was additionally treated with Danshen Chuanxiongqin injection based on the treatment of the control group.Both groups were treated for two courses,two weeks being a course.The clinical effects after treatment and the coagulation function,including activated partial thromboplastin time(APTT),plasma prothrombin time(PT)and fibrinogen(Fib),levels of serum inflammatory factors,including interleukin-1(IL-1),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α),and adverse reactions before and after treatment were compared the two groups.Results:The total effective rate was 95.34%in the observation group and81.39%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparisons of levels of APTT,PT and Fib between the two groups(P>0.05).After treatment,the levels of APTT and PT were increased when compared with those before treatment(P<0.05),the levels of Fib were decreased(P<0.05);the levels of APTT and PT in the observation group were obviously higher than those in the control group(P<0.05),the level of Fib in the observation was lower(P<0.05).Before treatment,there was no significant difference being found in the comparisons of levels of IL-1,IL-6 and TNF-αbetween the two groups(P>0.05);after treatment,the levels of IL-1,IL-6 and TNF-αin the two groups were decreased when compared with those before treatment(P<0.05),and the above three levels in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 9.30%in the observation group and 6.97%in the control group,there being no significance in the difference(P>0.05).Conclusion:The therapy of Danshen Chuanxiongqin injection combined with anticoagulant and thrombolysis has a significant effect on DVT after lower limb fracture,which can improve the coagulation function of patients and reduce the levels of inflammatory factors,with good administration safety.