富血小板纤维蛋白在慢性压力性损伤创面中的作用及研究进展

Role and progress of platelet-rich fibrin in wound of chronic pressure injury

压力性损伤是全世界常见的健康问题,常使患者处于疼痛、不适、焦虑状态,高昂的医疗费用给患者带来负面影响。目前现有治疗方法如创面清创换药、负压封闭引流、新型敷料、皮片或皮瓣转移等往往难以取得较好的疗效。目前第二代自体血小板衍生物富血小板纤维蛋白(Platelet-rich fibrin,PRF)被认为有较好的治疗前景,PRF为自体静脉血在无外源添加剂下经离心后分离出的淡黄色纤维凝胶状物质,因其制备简单、安全,且其中含有大量生长因子及抗炎因子,被认为一种对创面来说是很好的治疗选择。本文旨概述PRF的特性及优点、压力性损伤创面难愈机制、PRF对压力性损伤创面愈合作用机制,为今后此类创面治疗提供参考。

Pressure injury is a common health problem around the world,often putting patients in a state of pain,discomfort and anxiety,and the high medical costs bring a negative impact on patients.At present,existing treatments such as wound debridement and dressing,negative pressure closed drainage,new dressing,skin tablet or flap transfer are often difficult to achieve better results.The second generation of autologous platelet derivatives rich platelet protein(Platelet-rich fibrin,PRF)is considered to have a good treatment prospect,PRF for autologous venous blood without centrifugation after pale yellow fiber gel substance,because of its simple,safe,and contains a large number of growth factors and anti-inflammatory factors,is considered a good treatment choice for the wound.This paper aims to summarize the characteristics and advantages of PRF,the refractory mechanism of Pressure injury wound,and the mechanism of PRF on pressure injury wound healing,so as to provide a reference for the future treatment of such wound.