肠道菌群调节抑郁症机制及中医药防治研究进展

Research Progress on Mechanism of Intestinal Flora Regulating Depression and its Prevention and Treatment by Traditional Chinese Medicine

抑郁症是一种常见、多发的心理和精神疾病,病因尚未完全阐明。肠道菌群失调与抑郁症发病有关,其机制涉及炎症反应、单胺类神经递质、脑源性神经营养因子、下丘脑-垂体-肾上腺轴等多个方面。中医药治疗抑郁症具有独特优势且疗效显著,大量研究表明中医药可通过调节肠道菌群从而改善抑郁症状。就近年来肠道菌群参与抑郁症发病的作用机制以及中医药调节肠道菌群防治抑郁症的研究进行总结,以期为抑郁症的预防及相关中药的开发提供参考。

Depression is a common and prevalent psychological and psychiatric disorder, the etiology of which has not been fully elucidated.Intestinal flora imbalance is related to the pathogenesis of depression, and its mechanism involves inflammatory response, monoamine neurotransmitters, brain-derived neurotrophic factors, hypothalamus-pituitary-adrenal axis and other aspects.Traditional Chinese medicine has unique advantages and remarkable curative effect in the treatment of depression.A large number of studies have shown that traditional Chinese medicine can improve depressive symptoms by regulating intestinal flora.This article summarized the mechanism of intestinal flora involved in the pathogenesis of depression and the research of traditional Chinese medicine regulating intestinal flora to prevent and treat depression in recent years, in order to provide references for the prevention of depression and the development of related traditional Chinese medicines.