倾听脑神经细胞声音的机器人——面向脑科学研究的机器人化膜片钳系统

Robotic Listeners to the Whispers of Brain Neuron——Robotic Patch Clamp Systems for Brain Science Research

首先,根据操作对象的升级和操作方式改进过程对机器人化膜片钳的发展历程进行综述。进而,聚焦当前人类脑科学研究亟需的、面向清醒非人灵长类动物脑科学研究的机器人化膜片钳系统,对该系统在操作环境显示、操作工具与目标定位、操作工具的运动控制、测量信号的处理和操作对象固定5个方面存在的挑战及其潜在解决方法分别进行讨论分析。最后,在总结当前工作的基础上对今后面向脑科学研究的机器人化膜片钳的发展方向进行展望。

A development history of the robotic patch clamp system is reviewed firstly according to the upgrading of operation targets and the improvement of operation methods. Then, the robotic patch clamp system for the brain science research of awaken non-human primates, which is one of the highly-demanded devices in human brain science research, is focused in this paper. The 5 main challenges in the robotic patch clamp operation for awaken non-human primates, including display of the working environment, localization of the target cell and operation tool, motion control of the operation tool,processing of the measurement signal, and immobilization of awaken animal, are analyzed to determine the potential solutions for these challenges. Finally, the development directions of the robotic patch clamp system for brain science research in the future are predicted based on the above work.