早期肠内营养支持对胃癌术后患者肠黏膜屏障功能保护的研究进展

Research progress of early enteral nutrition support for the protection of intestinal mucous mucosal barrier function in patients with gastric cancer after surgery

胃癌患者在手术应激状况下,内脏血流减少,肠黏膜处于低灌注状态,易发生肠黏膜损伤。此外,手术刺激可导致肠黏膜充血、水肿、糜烂,加重肠黏膜损伤。近年来,肠内营养被作为保护肠黏膜屏障功能的有效手段。早期肠内营养在肠黏膜屏障功能保护中的作用机制已被证实,然而不同研究结果有一定差异。本研究综述了国内外有关胃癌术后患者行早期肠内营养支持的相关研究,整理、分析既往研究的结论和争议,为早期肠内营养支持的推广应用提供参考。

In patients with gastric cancer,the visceral blood flow is reduced and the intestinal mucosa is in a state of hypoperfusion,which is prone to intestinal mucosal injury.In addition,surgical stimulation can lead to congestion,edema,erosion of intestinal mucous membrane,aggravating intestinal mucous membrane injury.In recent years,enteral nutrition has been used as an effective method to protect intestinal mucous barrier function.The mechanism of early enteral nutrition in the protection of intestinal mucomucosal barrier function has been confirmed,but the results of different studies are different.This study reviewed the relevant studies at home and abroad on early enteral nutrition support for gastric cancer patients after surgery,sorted out and analyzed the conclusions and controversies of previous studies,and provided reference for the promotion and application of early enteral nutrition support.