PRR11在乳腺癌组织中的表达及与临床生物学行为和预后生存的关系

Expression of proline rich protein 11 in breast cancer and its relationship with clinical biological behavior,prognosis and survival

目的研究富脯氨酸蛋白11(prolinerich protein11,PRR11)在乳腺癌组织中的表达及与临床生物学行为和预后生存的关系。方法采用前瞻性分析法,选取2018年1月至2019年1月山西省长治医学院附属和平医院收治的乳腺癌患者80例。应用免疫组织化学SP法检测癌组织PRR11的表达情况,将PRR11表达为阳性的患者设为研究组(47例),将PRR11表达为阴性的患者设为对照组(33例),对所有患者随访3年,分析比较PRR11阳性、PRR11阴性表达患者生存率,通过Cox风险比例回归模型分析PRR11表达与临床生物学行为及预后生存的关系。ROC曲线分析PRR11对乳腺癌患者预后的预测价值。结果对80例患者进行3年的随访后发现,PRR11阴性表达患者的预后显著优于阳性表达患者,差异有统计学意义(χ^(2)=5.75,P<0.001)。用χ^(2)检验分析发现PRR11的表达与患者肿瘤大小、TNM分期、淋巴结转移、远处转移情况、组织学分级、Ki67表达、激素受体状态相关(P<0.05)。肿瘤较大、存在远处转移、分期较晚的乳腺癌组织中PRR11的表达相对较高(P<0.05)。单因素Cox回归模型分析显示,组织学分级、TNM分期、PRR11是影响乳腺癌患者预后的独立危险因素(P<0.001)。乳腺癌患者预后预测的AUC=0.812,95%CI=0.635~0.796,当PRR11表达为阳性时,敏感度为81.47%,特异度为85.57%。结论分期较晚的乳腺癌组织中PRR11的表达相对较高,PRR11表达与乳腺癌肿瘤大小、TNM分期、淋巴结转移等临床生物学行为密切相关,PRR11高表达患者生存率低,PRR11阳性表达是影响乳腺癌患者预后的独立危险因素,PRR11检测在乳腺癌预后判断中具有较好的临床应用价值。

Objective To study the expression of Proline rich protein11(PRR11)in breast cancer and its relationship with clinical biological behavior,prognosis and survival.Methods A prospective analysis method was used to select 80 patients with breast cancer from Jan.2018 to Jan.2019.Immunohistochemical S-P method was used to detect the expression of PRR11 in cancer tissues.Patients with positive expression of PRR11 were set as the study group(n=47)and the patients with negative expression of PRR11 were set as the control group(n=33).All patients were followed up for 3 years to analyze and compare the survival rates of patients with positive and negative expression of PRR11.The relationship between PRR11 expression and clinical biological behavior,prognosis and survival was analyzed by Cox risk ratio review model.Results 80 patients were followed up for 3 years.It was found that the prognosis of patients with negative PRR11 expression was significantly better than that of patients with positive PRR11 expression(χ^(2)=5.75,P<0.001).Chi square test was used to analyze the correlation between the expression of PRR11 and tumor size,TNM stage,lymph node metastasis,distant metastasis,histological grade,Ki67 expression and hormone receptor status(P<0.05).The expression of PRR11 in breast cancer tissues with larger tumors,distant metastasis and later staging was relatively high(P<0.05).Univariate Cox regression analysis showed that histological grade,TNM stage and PRR11 were independent risk factors affecting the prognosis of breast cancer patients(P<0.001).The AUC of prognosis prediction in patients with breast cancer was 0.812,and the 95%CI was 0.635-0.796.When PRR11 expression was positive,the sensitivity was 81.47%,and the specificity was 85.57%.Conclusions The expression of PRR11 is relatively high in the late stage breast cancer tissue.The expression of PRR11 is closely related to the clinical biological behavior of breast cancer size,TNM stage and lymph node metastasis.The survival rate of patients with high PRR11 expression is low,and the positive expression of PRR11 is an independent risk factor affecting the prognosis of breast cancer patients.PRR11 detection has preferable clinical application value in predicting the prognosis of breast cancer.