天然产物活性分子毛兰素抗肿瘤作用研究进展

Research progress on anti-tumor effect of natural product active molecule erianin

天然产物是抗癌药物的重要来源,通过对国内外现有研究的整理和分析,对药用植物铁皮石斛和鼓槌石斛中天然产物联苄类小分子毛兰素的抗肿瘤作用及其抗肿瘤分子机制进行综述。介绍石斛类天然产物的药用历史和药理活性,重点对毛兰素的多种药理作用尤其是其抗肿瘤作用进行分析,进一步结合多项体外及体内研究,阐述毛兰素对多种癌细胞株的肿瘤增殖抑制作用,通过对现有研究梳理,聚焦毛兰素通过诱导癌细胞凋亡、自噬,阻滞癌细胞周期,抑制癌细胞迁移侵袭,抑制肿瘤新生血管生成等多种分子机制发挥其肿瘤调控作用,并对JNK、PI3K/AKT、ERK等多条毛兰素相关信号通路及相关因子进行总结;最后,基于毛兰素的研究现状对其在成药研究及临床应用中的前景进行展望。

Natural products are an important source of anti-tumor drugs.Based on the sorting and analysis of current studies at home and abroad,this paper summarized the anti-tumor effect and anti-tumor molecular mechanism of bibenzyl small molecule erianin in medicinal plants Dendrobium candidum and Dendrobium chrysotoxum.Firstly,the medicinal history and pharmacological activities of Dendrobium natural products,as well as the various pharmacological effects of erianin,especially its antitumor effects were introduced and explored.Combined with a number of in vitro and in vivo studies,the inhibitory effects of erianin on tumor proliferation of many cancer cell lines were introduced.By combing and analyzing the available research,this paper analyzed the role of erianin in tumor regulation by inducing cancer cell apoptosis,autophagy,blocking cancer cell cycle,inhibiting cancer cell migration and invasion,inhibiting tumor angiogenesis and other molecular mechanisms,and summarized several erianin related signal pathways and factors such as JNK,PI3K/Akt,ERK.Finally,in view of research status of erianin.The prospect of erianin in patent medicine research and clinical application was prospected.