更昔洛韦治疗对小儿流行性腮腺炎合并脑膜炎临床疗效及不良反应的影响

Effects of Ganciclovir Treatment on Clinical Efficacy and Adverse Reactions of Juvenile Mumps Complicated with Meningitis

目的:探讨更昔洛韦治疗对小儿流行性腮腺炎合并脑膜炎的临床效果.方法:选取2015年6月至2021年2月本院收治的流行性腮腺炎合并脑膜炎患儿86例为研究对象.将其随机分为观察组(n=43,常规治疗+更昔洛韦)和对照组(n=43,仅常规治疗).治疗后观察患儿临床效果及不良反应发生情况.结果:观察组总有效率为97.67%,明显高于对照组79.06%(P<0.05);观察组患儿退热、头痛消失、腮腺肿大消退时间及神经症状缓解时间、住院时间均明显短于对照组(P<0.05);治疗后,两组白细胞介素(IL)-6和肿瘤坏死因子(TNF)-α水平均降低,且观察组低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P=0.152).结论:更昔洛韦治疗小儿流行性腮腺炎合并脑膜炎临床疗效显著.

Objective:To investigate the clinical efficacy and adverse reactions of ganciclovir treatment on juvenile mumps complicated with meningitis.Methods:A total of 86 patients with mumps complicated with meningitis admitted to our hospital from June 2015 to February 2021 were selected as research subjects and were randomly divided into an observation group(n=43,conventional treatment+ganciclovir)and a control group(n=43,conventional treatment only).The clinical effects and adverse reactions were observed and compared after treatment.Results:The total effective rate of the observation group was 97.67%,which was significantly higher than 79.06%of the control group(P<0.05).The time of fever reduction,headache disappearance,parotid gland enlargement resolution,neurological symptoms relief and hospital stay in the observation group were significantly shorter than those in the control group(P<0.05).After treatment,the levels of interleukin(IL)-6 and tumor necrosis factor(TNF)-αdecreased in two groups,which were lower in the observation group than those in the control group(P<O.05).There was no difference in the incidence of adverse reactions between the two groups(P=0.152).Conclusion:Ganciclovir is effective in the treatment of epidemic parotitis complicated with meningitis in children.