松龄血脉康联合厄贝沙坦氢氯噻嗪治疗老年高血压的效果及对其血管内皮功能、心室重构的影响

Curative Effect of Songling Xuemaikang Combined with Irbesartan/hydrochlorothiazide on Elderly Hypertension and Its Influences on Vascular Endothelial Function and Ventricular Remodeling

目的:探讨松龄血脉康联合厄贝沙坦氢氯噻嗪治疗老年高血压的效果及对其血管内皮功能、心室重构的影响.方法:选取2019年11月至2021年11月,本院收治的老年高血压患者80例作为研究对象,采用随机数字表法分为观察组和对照组,每组40例.观察组口服厄贝沙坦氢氯噻嗪和松龄血脉康,对照组口服厄贝沙坦氢氯噻嗪.观察两组患者治疗效果,比较治疗前、后两组患者血压、血管内皮功能指标变化及心室重构情况.结果:观察组治疗24h后收缩压、舒张压、收缩压变异性(SBPV)、舒张压变异性(DBPV),水平均低于对照组(P<0.05);观察组治疗后内皮素(ET-1)水平低于对照组,一氧化氮(NO)高于对照组,(P<0.05);观察组治疗后左心室射血分数(LVEF)、左心室短轴缩短率(FS)均高于对照组,观察组治疗后左心室舒张末期内径(LVEDD)、左心室质量指数(LVMI)均低于对照组.结论:采用松龄血脉康联合厄贝沙坦氢氯噻嗪治疗高血压的效果显著,可改善血管内皮功能,缓解心室重构.

Objective:To explore the curative effect of songling xuemaikang combined with irbesartan/hydrochlorothiazide on elderly hypertension and its influences on vascular endothelial function and ventricular remodeling.Methods:A total of 80 patients with hypertension were enrolled as the research objects between November 2019 and November 2021.According to random number table method,they were divided into observation group and control group,40 cases in each group.The observation group was given oral songling xuemaikang combined with irbesartan/hydrochlorothiazide,and the control group was given oral irbesartan/hydrochlorothiazide.The curative effect in both groups was observed.The changes of blood pressure and vascular endothelial function indexes before and after treatment,and ventricular remodeling were compared between the two groups.Results:At 24h after treatment,levels of systolic blood pressure,diastolic blood pressure,systolic blood pressure variability(SBPV)and diastolic blood pressure variability(DBPV)in observation group were lower than those in control group(P<0.05).After treatment,level of endothelin-1(ET-1)in observation group was lower than that in control group,while nitric oxide(NO)was higher than that in control group(P<0.05).After treatment,left ventricular ejection fraction(LVEF)and left ventricular fractional shortening(FS)in observation group were higher than those in control group,while left ventricular end-diastolic diameter(LVEDD)and left ventricular mass index(LVMI)were lower than those in control group.Conclusion:Curative effect of songling xuemaikang combined with irbesartan/hydrochlorothiazide is significant on hypertension,which can improve vascular endothelial function and relieve ventricular remodeling.