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参松养心胶囊对气阴两虚型糖尿病心血管自主神经病变患者血液流变学和心血管功能的影响 被引量:2

Effects of Shensong Yangxin Capsules on Hemorheology and Cardiovascular Function in Patients with Diabetic Cardiovascular Autonomic Neuropathy of Qi and Yin Deficiency
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摘要 目的:探讨参松养心胶囊对气阴两虚型糖尿病心血管自主神经病变患者血液流变学和心血管功能的影响。方法:采用随机数字表法将2018年7月至2020年3月南通大学附属海安医院收治的气阴两虚型糖尿病心血管自主神经病变患者130例分为对照组和观察组,每组65例。对照组患者给予糖尿病基础和营养治疗,观察组患者加用参松养心胶囊治疗。观察两组患者临床疗效,血液流变学、心血管功能和症状评分指标变化,以及心血管不良事件和药品不良反应发生情况。结果:治疗12周后,观察组患者纤维蛋白原和D-二聚体水平,自主神经症状量表、复合自主神经症状评分-31均较治疗前和对照组显著降低,QT离散度和Valsalva动作指数较治疗前和对照组显著升高,差异均有统计学意义(P<0.05)。治疗12周后,观察组患者的治疗总有效率为95.38%(62/65),高于对照组的83.08%(54/65),差异有统计学意义(P<0.05)。随访6个月,观察组患者心血管不良事件发生率为6.15%(4/65),低于对照组的12.31%(8/65),差异有统计学意义(P<0.05)。结论:采用参松养心胶囊辅助治疗气阴两虚型糖尿病心血管自主神经病变患者,能改善其血液流变学,提高心血管功能,缓解临床症状,改善疾病预后,用药安全性较高。 OBJECTIVE:To probe into the effects of Shensong Yangxin capsules on hemorheology and cardiovascular function in patients with diabetic cardiovascular autonomic neuropathy of Qi and Yin deficiency.METHODS:A total of 130 patients with diabetic cardiovascular autonomic neuropathy of Qi and Yin deficiency admitted into Hai’an Hospital Affiliated to Nantong University from Jul.2018 to Mar.2020 were selected to be divided into control group and observation group by random number table method,with 65 cases in each group.The control group was given basic and nutritional treatment of diabetes,while the observation group was treated with Shensong Yangxin capsules.The clinical efficacy,changes of indicators of hemorheology,cardiovascular function and symptom scores,incidences of adverse cardiovascular events and adverse drug reactions of two groups were observed.RESULTS:After 12 weeks of treatment,the fibrinogen and D-dimer levels,the autonomic symptoms scale and composite autonomic symptoms score-31 in the observation group were significantly lower than those before treatment and in the control group,the QT dispersion and Valsalva action index in the observation group were significantly higher than those before treatment and in the control group,with statistically significant differences(P<0.05).After 12 weeks of treatment,the total effective rate of the observation group was 95.38%(62/65),which was higher than that of control group(83.08%,54/65),with statistically significant difference(P<0.05).After 6 months of follow-up,the incidences of cardiovascular adverse events of the observation group was 6.15%(4/65),lower than 12.31%(8/65)of the control group,with statistically significant difference(P<0.05).CONCLUSIONS:The application of Shensong Yangxin capsules on patients with diabetic cardiovascular autonomic neuropathy of Qi and Yin deficiency can improve patients’hemorheology,promote cardiovascular function,relieve clinical symptoms,improve prognosis,with higher medication safety.
作者 蔡晖娟 谢海洋 黄兰薰 CAI Huijuan;XIE Haiyang;HUANG Lanxun(Dept.of Endocrinology,Hai’an Hospital Affiliated to Nantong University,Jiangsu Hai’an 226600,China;Dept.of Endocrinology,Nantong Ruici Hospital,Jiangsu Nantong 226010,China)
出处 《中国医院用药评价与分析》 2022年第11期1349-1352,1356,共5页 Evaluation and Analysis of Drug-use in Hospitals of China
基金 南通市2019年度市级科技计划项目(No.MSZ19032)。
关键词 糖尿病心血管自主神经病变 气阴两虚型 参松养心胶囊 血液流变学 心血管功能 Diabeticcardiac autonomic neuropathy Qi and Yin deficiency Shensong Yangxin capsules Hemo-rheology Cardiovascular function
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