丹参多酚酸盐对老年急性心肌梗死患者经皮冠状动脉介入术后炎症反应和血管内皮功能的影响

Effects of Salvia Miltiorrhiza Polyphenolate on Inflammatory Reaction and Vascular Endothelial Function After Percutaneous Coronary Intervention in Elderly Patients with Acute Myocardial Infarction

目的探讨丹参多酚酸盐对老年急性心肌梗死患者经皮冠状动脉介入术(PCI)后炎症反应及血管内皮功能的影响。方法选取2019年1月至2021年3月在郑州人民医院接受PCI手术的128例老年急性心肌梗死患者作为研究对象,按照随机数字表法分为观察组(64例)和对照组(64例)。对照组术后接受阿司匹林、氯吡格雷和培哚普利等药物治疗,观察组在对照组的基础上加用丹参多酚酸盐治疗,疗程为14 d。比较两组患者治疗后血清炎症细胞因子、细胞黏附因子和血管内皮功能指标以及随访6个月内不良心血管事件发生率。结果两组患者PCI术后14 d时,血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)水平均较术后1 d降低,且观察组低于对照组(P<0.05)。两组患者PCI术后14 d时,血清一氧化氮(NO)浓度较术后1 d升高,且观察组高于对照组(P<0.05);血清内皮素-1(ET-1)和血管性血友病因子(vWF)较术后1 d降低,且观察组低于对照组(P<0.05)。观察组患者PCI术后不良心血管事件发生率低于对照组(P<0.05)。结论丹参多酚酸盐能够改善老年急性心肌梗死患者PCI术后炎症反应和血管内皮功能相关指标,减少不良心血管事件发生。

Objective To investigate the effect of salvia miltiorrhiza polyphenolate on inflammatory reaction and vascular endothelial function after percutaneous coronary intervention(PCI)in elderly patients with acute myocardial infarction.Methods A total of 128 elderly patients with acute myocardial infarction who underwent PCI in Zhengzhou People’s Hospital from January 2019 to March 2021 were selected as research objects,and were divided into observation group(64 cases)and control group(64 cases)according to random number method.The control group received aspirin,clopidogrel,perindopril and other drugs after surgery.The observation group was treated with salvia miltiorrhiza polyphenolate on the basis of the control group,with a course of 14 days.The serum inflammatory cytokines,adhesion cytokines and vascular endothelial function were compared between the two groups after treatment,as well as the incidence of adverse cardiovascular events within 6 months of follow-up.Results At 14 days after PCI,the levels of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),intercellular adhesion molecule-1(ICAM-1)and vascular cell adhesion molecule-1(VCAM-1)in the two groups were lower than 1 day after operation,and those in the observation group were lower than in the control group(P<0.05).On the 14th day after PCI,the concentration of serum nitric oxide(NO)in the two groups was higher than that on the 1st day after PCI,and that in the observation group was higher than that in the control group(P<0.05).On the 14th after PCI,serum endothelin-1(ET-1)and von willebrand factor(vWF)were lower than 1 day after operation,and those in the observation group were lower than in the control group(P<0.05).The incidence of adverse cardiovascular events after PCI in the observation group was lower than that in the control group(P<0.05).Conclusion Salvia miltiorrhiza polyphenolate can improve the inflammatory reaction and vascular endothelial function related indicators in elderly patients with acute myocardial infarction after PCI,and reduce adverse cardiovascular events.