氟哌利多复合全凭静脉麻醉在胃癌根治术患者中的应用效果

Effect of Droperidol Combined with Total Intravenous Anesthesia in Patients Undergoing Radical Gastrectomy

目的探究氟哌利多复合全凭静脉麻醉在胃癌根治术患者中的应用效果。方法选取2019年2月至2020年2月于商丘市梁园区中医院接受胃癌根治术的126例患者作为研究对象,按照随机数字表法分为全凭静脉麻醉组和联合组,各63例。全凭静脉麻醉组患者术前接受全凭静脉麻醉,联合组患者术前接受氟哌利多复合全凭静脉麻醉。比较两组患者气腹前后pH、二氧化碳总量、二氧化碳分压水平;比较两组患者苏醒质量;比较两组患者血清T淋巴细胞亚群、促肾上腺皮质激素(ACTH)、皮质醇(Cor)、内皮素(ET-1)、超敏C反应蛋白(hs-CRP)、白介素-8(IL-8)、白介素-17(IL-17)水平。结果气腹后,联合组患者pH高于全凭静脉麻醉组患者,二氧化碳总量、二氧化碳分压水平低于全凭静脉麻醉组患者(P<0.05)。联合组患者自主呼吸恢复、定向力恢复、拔出气管插管时间短于全凭静脉麻醉组患者(P<0.05)。手术后,联合组患者CD8^(+)水平低于全凭静脉麻醉组患者,CD4^(+)、CD3^(+)水平高于全凭静脉麻醉组患者(P<0.05)。手术后,联合组患者血清ACTH、Cor、ET-1、hs-CRP、IL-8、IL-17水平低于全凭静脉麻醉组患者(P<0.05)。结论使用氟哌利多复合全凭静脉麻醉对接受胃癌根治术治疗患者进行麻醉干预,患者血气指标较为稳定,苏醒质量更加理想,免疫功能受影响较小,手术应激反应较轻,炎症反应较轻,有利于患者身体恢复。

Objective To investigate the effect of droperidol combined with total intravenous anesthesia in patients undergoing radical gastrectomy.Methods A total of 126 patients who received radical gastrectomy in Liangyuan Hospital of Traditional Chinese Medicine of Shangqiu City from February 2019 to February 2020 were selected as the research objects,and they were divided into total intravenous anesthesia group and combined group according to the random number table method,with 63 patients in each group.Patients in total intravenous anesthesia group received total intravenous anesthesia before operation,and patients in combined group received droperidol combined with total intravenous anesthesia before operation.The pH,total carbon dioxide and partial pressure of carbon dioxide before and after pneumoperitoneum were compared between the two groups.The quality of recovery was compared between the two groups.The levels of serum T lymphocyte subsets,adreno-cortico-tropic-hormone(ACTH),cortisol(Cor),endothelin(ET-1),hypersensitive C-reactive protein(hs-CRP),interleukin-8(IL-8)and interleukin-17(IL-17)were compared between the two groups.Results After pneumoperitoneum,the pH level of patients in the combined group was higher than that in the total intravenous anesthesia group,and the total carbon dioxide and partial pressureof carbon dioxide were lower than those in the total intravenous anesthesia group(P<0.05).The time of spontaneous respiration recovery,orientation recovery and tracheal extubation in the combined group was shorter than that in the total intravenous anesthesiagroup(P<0.05).After operation,the level of CD8^(+)in the combined group was lower than that in the total intravenous anesthesia group,and the levels of CD4^(+)and CD3^(+)were higherthan those in the total intravenous anesthesia group(P<0.05).After operation,the levels ofserum ACTH,Cor,ET-1,hs-CRP,IL-8,IL-17 in the combined group were lower than those in the total intravenous anesthesia group(P<0.05).Conclusion Using droperidol combined with total intravenous anesthesia to perform anesthesia intervention on patients undergoing radical gastrectomy for gastric cancer,the patient’s blood gas index is more stable,the quality of recovery is more ideal,the immune function is less affected,the surgical stress response is less,and the inflammatory response is less,which is conducive to the patient’s physical recovery.