沉默信息调节因子在脑缺血再灌注损伤中的作用及中医药干预研究进展

Role of SIRTs in cerebral ischemia reperfusion injury and targeted intervention of Chinese medicine

脑缺血再灌注损伤(CIRI)是一种复杂的级联反应,严重阻碍急性缺血性中风患者的康复,成为一个亟需解决的难题。沉默信息调节因子(SIRTs)是一个依赖于烟酰胺腺嘌呤二核苷酸(NAD^(+))的去乙酰化酶家族,具有对组蛋白和非组蛋白的赖氨酸基团去酰化功能。较多研究显示,SIRTs可通过对蛋白质翻译后去乙酰化,参与调控CIRI过程中氧化应激、炎症反应、线粒体功能失调以及细胞程序性死亡等多种病理过程,发挥脑保护作用。该文综述了近10年来国内外有关SIRTs在CIRI病理过程中的作用与机制,并对中医药靶向SIRTs及其通路防治CIRI的相关研究进展,进行追踪总结,试图为中医药对缺血性脑卒中CIRI的康复治疗提供新靶标及其理论支持。

Cerebral ischemia-reperfusion injury(CIRI)is a complex cascade process and seriously hinders the recovery of patients with acute ischemic stroke,which has become an urgent public health issue to be addressed.Silent information regulators(SIRTs)are a family of nicotinamide adenine dinucleotide(NAD)-dependent deacetylases,capable of deacylating the histone and non-histone lysine groups.Accumulating evidence has demonstrated that SIRTs are able to regulate the pathological processes such as oxidative stress,inflammatory response,mitochondrial dysfunction,and programmed cell death of CIRI through post-translational deacetylation,and exert the neuroprotection function.In this study,we reviewed the papers about the role and regulatory mechanisms of SIRTs in the pathological process of CIRI published in the past decade.Further,we summarized the research advance in the prevention and treatment of CIRI with Chinese medicine targeting SIRTs and the related signaling pathways.This review will provide new targets and theoretical support for the clinical application of Chinese medicine in treating CIRI during the occurrence of ischemic stroke.