基于数据挖掘探究中药治疗心肌梗死后心力衰竭的用药规律

Medication rule of traditional Chinese medicine for heart failure after myocardial infarction: based on data mining

基于数据挖掘技术总结中药治疗心肌梗死后心力衰竭的用药规律。检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed),筛选中药治疗心肌梗死后心力衰竭的相关文献并提取资料。使用Microsoft Excel 2019建立数据库,应用SPSS Clementine 12.0和IBM SPSS Statistics 23.0软件进行关联规则分析、聚类分析和因子分析。共纳入中医处方81首,涉及单味中药91味,中药累计使用频次740次,主要证型为气虚血瘀证、阳气亏虚血瘀证兼水饮、气阴两虚血瘀证。使用频次较高的中药依次是黄芪、丹参、人参、茯苓、附子。药物功效以补虚药、活血化瘀药和利水渗湿药为主。关联规则分析得到“黄芪-丹参”“黄芪-附子-丹参”“附子-人参-丹参-黄芪”等常用中药组合;聚类分析得到治疗心肌梗死后心力衰竭的潜在基础方6个;因子分析共提取8个公因子。心肌梗死后心力衰竭为本虚标实之证,核心病机为“虚”“瘀”“水”,以“虚”最为主要,与心、肺、脾三脏关系密切,治法以益气活血为主,兼以温阳、利水、养阴等,挖掘出四物汤、生脉散、血府逐瘀汤、苓桂术甘汤、参附汤等常用基础方,为心肌梗死后心力衰竭临床用药以及药物研发提供了数据支撑。

This study aims to explore the medication rule of traditional Chinese medicine(TCM) for heart failure after myocardial infarction via data mining. To be specific, articles on the treatment of the disease with Chinese medicine were retrieved from CNKI, Wanfang, VIP, and SinoMed and related information was collected. A database was created with Microsoft Excel 2019, and SPSS Clementine 12.0 and IBM SPSS Statistics 23.0 were applied for association rules analysis, cluster analysis, and factor analysis. Finally, a total of 81 TCM prescriptions were screened out, involving 91 medicinals with cumulative use frequency of 740. The main syndromes were Qi deficiency and blood stasis, Yang Qi deficiency and blood stasis together with retained morbid fluid, deficiency of both Qi and Yin and blood stasis. The medicinals with high-frequency were Astragali Radix, Salviae Miltiorrhizae Radix et Rhizoma, Ginseng Radix et Rhizoma, Poria, and Aconiti Lateralis Radix Praeparata. The effects of the medicinals were tonifying deficiency, activating blood and resolving stasis, and promoting urination and draining dampness. The association rules analysis yielded "Astragali Radix-Salviae Miltiorrhizae Radix et Rhizoma" "Astragali Radix-Aconiti Lateralis Radix Praeparata-Salviae Miltiorrhizae Radix et Rhizoma" "Aconiti Lateralis Radix Praeparata-Ginseng Radix et Rhizoma-Salviae Miltiorrhizae Radix et Rhizoma-Astragali Radix" combinations. Cluster analysis yielded 6 basic formulas for heart failure after myocardial infarction. Factor analysis extracted a total of 8 common factors. Heart failure after myocardial infarction is characterized by the syndrome of deficiency in nature and excess in superficiality. The core pathogenesis is "deficiency" "stasis" "retained morbid fluid", particularly "deficiency". This disease is closely related to the heart, lung, and spleen. The basic treatment principle is replenishing Qi and activating blood, and warming Yang, excreting water, and nourishing yin should also be emphasized. The common basic prescriptions, such as Siwu Decoction, Shengmai Powder, Xuefu Zhuyu Decoction, Linggui Zhugan Decoction, and Shenfu Decoction, have been discovered. This study provided data for clinical medication and drug development for heart failure after myocardial infarction.