小柴胡汤加减治疗慢性结肠炎疗效观察

Observation of Therapeutic Efficacy of Minor Bupleurum Decoction on Chronic Colitis

目的:观察小柴胡汤加减治疗慢性结肠炎的临床疗效。方法:选择2019年1月至2021年5月在上饶市广丰区人民医院治疗的慢性结肠炎患者126例,随机分为对照组和治疗组,每组各63例。对照组采用常规西医治疗,治疗组在对照组治疗的基础上采用小柴胡汤加减治疗,两组均以10 d为1个疗程,连续治疗4个疗程。比较两组患者临床疗效、中医证候积分、血清炎性因子、代谢功能及免疫功能指标变化情况。结果:对照组有效率为82.54%,治疗组有效率为95.24%,两组有效率比较,差异有统计学意义(P<0.05);两组患者治疗后各中医证候积分均降低,与治疗前比较,差异有统计学意义(P<0.05),且组间比较,差异有统计学意义(P<0.05);两组患者治疗后血清白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)水平降低,IL-10升高,与治疗前比较,差异有统计学意义(P<0.05),且组间比较,差异有统计学意义(P<0.05);两组患者治疗后D-木糖排泄率、唾液淀粉酶活性均较前升高,与治疗前比较,差异有统计学意义(P<0.05),且组间比较,差异有统计学意义(P<0.05);两组患者治疗后CD3^(+)、CD8^(+)降低,CD4^(+)升高,与治疗前比较,差异有统计学意义(P<0.05),且组间比较,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小柴胡汤加减治疗慢性结肠炎可明显改善患者症状,提高机体免疫功能,且无明显不良反应。

Objective:To observe the clinical efficacy of Minor Bupleurum Decoction on chronic colitis.Methods:A total of 126 patients with chronic colitis who were treated in Guangfeng District People′s Hospital of Shangrao City from January 2019 to May 2021 were selected and randomly divided into the control group and the treatment group,with 63 cases in each group.The control group was treated with conventional Western medicine,while the treatment group was treated with Minor Bupleurum Decoction on the basis of the control group.Both groups took 10 days as a course of treatment,with 4 consecutive courses of treatment.The clinical efficacy,TCM syndrome score,serum inflammatory factors,metabolic function and immune function indexes of the two groups were compared.Results:The effective rate of the control group was 82.54%,and the effective rate of the treatment group was 95.24%.The difference between the two groups was statistically significant(P<0.05).After treatment,each TCM syndrome score of the two groups was lower than that before treatment,and the difference was statistically significant(P<0.05),and the difference between the two groups was also statistically significant(P<0.05).After treatment,serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and the level of hypersensitive C-reactive protein(hs-CRP)decreased,while IL-10 increased.Compared with that before treatment,all the differences were statistically significant(P<0.05),and the differences between two groups were also statistically significant(P<0.05).After treatment,the excretion rate of D-xylose and the activity of salivary amylase in both groups increased.Compared with those before treatment,all the differences were statistically significant(P<0.05),and the differences between the two groups were also statistically significant(P<0.05).After treatment,the levels of CD3^(+) and CD8^(+) decreased,and while the level of CD4^(+) increased in the two groups,compared with those before treatment,all the differences were statistically significant(P<0.05),and the differences between the two groups were also statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Modified Minor Bupleurum Decoction can obviously improve the symptoms of patients with chronic colitis,enhance the immune function of the body,and there are no obvious adverse reactions.