补肾促卵方治疗肾虚肝郁型卵巢功能低下所致不孕症临床研究

Clinical Study on the Treatment of Infertility Caused by Decreased Ovarian Reserve of Kidney Deficiency and Liver Depression with Kidney-Tonifying and Follicle-Stimulating Decoction

目的:观察补肾促卵方治疗肾虚肝郁型卵巢功能低下所致不孕症的临床疗效。方法:将100例卵巢功能低下所致不孕症患者按照随机数字表法分为观察组和对照组,每组各50例。对照组给予雌二醇/雌二醇地屈孕酮复合片口服,观察组在对照组治疗的基础上给予补肾促卵方治疗。比较两组患者的临床疗效、妊娠率及治疗前后激素水平[卵泡刺激素(follicle stimulate hormone,FSH)、促黄体生成素(luteinizing Hormone,LH)、雌二醇(estradiol,E_(2))]、卵巢功能、卵巢血流状态[子宫动脉收缩期峰值流速(peak systolic velocity,PSV)、窦卵泡计数(antral follicle count,AFC)、搏动指数(pulsation index,PI)、血管阻力指数(resistance index,RI)]变化情况。结果:观察组有效率为96.00%,对照组有效率为80.00%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后血清激素FSH、LH、E_(2)、FSH/LH水平均低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后初级卵泡数、优势卵泡、排卵数、子宫内膜厚度高于本组治疗前,且治疗后观察组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后PSV、RI、AFC高于本组治疗前,PI低于本组治疗前,组间比较,差异均有统计学意义(P<0.05)。观察组妊娠率高于对照组,差异具有统计学意义(P<0.05)。结论:补肾促卵方治疗卵巢功能低下所致不孕症,可改善患者卵巢功能,调节性激素水平,提高妊娠率。

Objective:To observe the clinical efficacy of Kidney-Tonifying and Follicle-Stimulating Decoction on infertility caused by decreased ovarian reserve(DOR)of kidney deficiency and liver depression.Methods:A total of 100 patients with infertility caused by DOR were randomly divided into the observation group and the control group,with 50 cases in each group.The control group was treated with Estradiol/Estradiol Didrosterone Compound Tablets orally,while the observation group was treated with Kidney-Tonifying and Follicle-Stimulating Decoction on the basis of the control group.The clinical efficacy,pregnancy rate,the changes of hormone levels[including follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2))],ovarian function,and ovarian blood flow status[including peak systolic velocity(PSV),sinus follicle count(AFC),pulsation index(PI),and vascular resistance index(RI)]were compared.Results:The effective rate was 96.00%in the observation group and 80.00%in the control group.The difference between the two groups was statistically significant(P<0.05).After treatment,the levels of serum hormones FSH,LH,E_(2),FSH/LH in the two groups were lower than those of the same group before treatment,and the above levels in the observation group were lower than those in the control group after treatment,and all the differences were statistically significant(P<0.05).After treatment,the number of primary follicles,the number of dominant follicles,the number of ovulation,and the thickness of endometrium in the two groups were higher than those of the same group before treatment,and the number of each index in the observation group was higher than that in the control group,and all the differences were statistically significant(P<0.05).After treatment,PSV,RI and AFC of patients in the two groups were higher than those of the same group before treatment,while PI was lower than that before treatment.and all the differences were statistically significant(P<0.05).The pregnancy rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Kidney-Tonifying and Follicle-Stimulating Decoction can improve the ovarian function of patients with infertility caused by DOR,regulate the level of sex hormones and increase the pregnancy rate.