摘要
Inmost existingmethods and softwares of genome-wide association studies(GWAS)fordetecting quantitative trait nucleotides(QTNs),QTN-by-environment interactions(QEls),and QTN-by-QTN interactions(QQIs),only the allele substitution effect and its interaction-related effects are detected and estimated,conditional on method-specific polygenic background control,leading to confounding in effect estimation and insufficient polygenic background control(Li et al.,2022;Supplemental Tables 1-3).
基金
This work was supported by the National Natural Science Foundation of China(32070557,31871242)
the Huazhong Agricultural University Scientific&Technological Self-InnovationFoundation(2014RC020).
