支气管扩张症患者肺部微生态研究进展

Research progress of pulmonary microbiome in patients with bronchiectasis

支气管扩张症近年来发病率及患病率显著升高, 其发病与加重机制尚未完全阐明, 有研究表明, 肺部微生物群的构成和丰度变化是导致支气管扩张患者病情加重的重要原因之一, 因而受到广泛关注。支气管扩张症患者肺部有多种微生物定植, 其中, 不同患者肺部定植的核心菌群不同, 以铜绿假单胞菌为代表的核心菌定植是导致支气管扩张症患者肺功能下降和加重频率增加的独立危险因素。本文就支气管扩张症稳定期和加重期肺部微生态的变化进行综述, 希望对支气管扩张症的治疗带来启发。

The incidence and prevalence of bronchiectasis have increased significantly in recent years.However,the pathogenesis and aggravation mechanism of bronchiectasis has not been fully elucidated.Some studies show that the composition and abundance change of pulmonary microbiome is one of the most important reasons for the aggravation of bronchiectasis.Therefore,it has attracted wide attention.There are many kinds of microbial colonization in the lung of patients with bronchiectasis.The core bacterial colonization varies from patients to patients.The colonization of core bacteria represented by Pseudomonas aeruginosa is an independent risk factor for the decline of lung function and increase of exacerbation frequency in patients with bronchiectasis.This article reviews the changes of pulmonary microbiome in stable and aggravated bronchiectasis,so as to provide guidance to the treatment of bronchiectasis.