慢性肾脏病患者主要心血管不良事件危险因素的临床研究与进展

Clinical researchs and advances of risk factors for major cardiovascular adverse events in patients with chronic kidney diseases

慢性肾脏病(chronic kidney disease,CKD)患者由于肾脏结构与功能损伤,引发全身多种并发症及多器官功能损害,降低患者生活质量,严重威胁患者生命健康,其中主要心血管不良事件(major adverse cardiovascular events,MACE)是导致患者预后不良的重要原因。然而,普通人群MACE危险因素在指导CKD临床治疗与风险评价时具有一定局限性。近年随着医学水平的进步,针对识别和评价CKD患者MACE危险因素的研究有了较大发展,多种临床指标与参数被纳入研究。本文现就此做一综述,以便为临床工作提供参考。

Chronic kidney disease(CKD)patients have a variety of systemic complications and multiple organ dysfunctions due to the injuries of renal structures and functions,compromising quality-oflife and seriously threatening patient well-being.Among these CKDs,major cardiovascular adverse events(MACE)lead to adverse outcomes.However,risk factors of MACE in general population have certain limitations in guiding clinical treatments and risk evaluations of CKD patients.With recent medical advances,identifying and evaluating risk factors for MACE have made great strides in CKD patients and a large variety of clinical indicators and parameters have been adopted for researches.Here current understanding of risk factors of MACE of CKD patients was summarized to provide references for clinical practices.