丁苯酞联合多奈哌齐治疗阿尔茨海默病临床观察

Clinical Observation of Butylphthalide Combined with Donepezil in the Treatment of Alzheimer’s Disease

目的探究丁苯酞联合多奈哌齐治疗阿尔茨海默病(Alzheimer’s disease,AD)的效果。方法选取老年AD患者80例作为研究对象,采用随机数字表法分为观察组(n=41)和对照组(n=39),对照组采用盐酸多奈哌齐片治疗,观察组采用盐酸多奈哌齐片+丁苯酞胶囊治疗。比较2组患者的临床疗效、用药前后血脂水平、认知功能障碍及药物相关不良反应。结果观察组治疗有效率90.24%,高于对照组的71.79%,差异有统计学意义(P<0.05)。治疗前,2组患者血脂指标血清总胆固醇(TC)、三酰甘油(TG)水平比较,差异无统计学意义(P>0.05)。治疗后,观察组TC与TG水平较治疗前降低,差异有统计学意义(P<0.05)。治疗后,对照组TC与TG水平与治疗前比较无明显变化,差异无统计学意义(P>0.05)。治疗后,观察组TC与TG水平低于对照组,差异有统计学意义(P<0.05)。治疗前,2组患者简易智力状态检查量表(MMSE)评分比较,差异无统计学意义(P>0.05)。治疗后,2组MMSE评分较治疗前增加,差异有统计学意义(P<0.05)。治疗后,观察组MMSE评分高于对照组,差异有统计学意义(P<0.05)。观察组药物相关性不良反应发生率为7.32%,对照组为5.13%,差异无统计学意义(P>0.05)。结论AD患者采用丁苯酞联合多奈哌齐治疗,临床疗效较好,患者血脂水平、MMSE评分均得到改善,且用药较安全。

Objective To investigate the effect of butylphthalide combined with donepezil in the treatment of Alzheimer’s disease(AD).Methods A total of 80 elderly AD patients were selected as the research objects and divided into an observation group(n=41)and a control group(n=39)by random number table method.Patients in the control group were treaded with Donepezil Hydrochloride Tables,and patients in observation group were treaded with Donepezil Hydrochloride Tables and Butylphthalide Capsules.The clinical efficacy,blood lipid levels,cognitive dysfunction and drug-related adverse reactions before and after treatment were compared between the two groups.Results The effective rate of treatment in the observation group was 90.24%,which was higher than 71.79% in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in serum total cholesterol(TC)and triacylglycerol(TG)levels of blood lipid indexes between the two groups(P>0.05).After treatment,the levels of TC and TG in the observation group were lower than those before treatment,and the difference was statistically significant(P<0.05).After treatment,in the control group,the levels of TC and TG did not change significantly compared with those before treatment,and the difference was not statistically significant(P>0.05).After treatment,the levels of TC and TG in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in MMSE scores between the two groups before treatment(P>0.05).After treatment,the MMSE scores of the two groups increased compared with those before treatment,and the difference was statistically significant(P<0.05).After treatment,the MMSE score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The incidence of drug-related adverse reactions in the observation group was 7.32%,and that in the control group was 5.13%,and the difference was not statistically significant(P>0.05).Conclusion The clinical efficacy of butylphthalide combined with donepezil in AD patients is definite,and the blood lipids and MMSE scores of the patients are significantly improved,and the medication is safe.