摘要
A breakthrough article by Yao et al.(2022),published in the journal Cell,performed systematic cryo-electron microscopic structure analysis of Cav1.1 and Cav1.3 treated with AMIO or SOF alone or SOF/MNI-1 combined with AMIO[1].DDI between the antiviral drug SOF and the antiarrhythmic drug AMIO have been reported to cause severe slowing of heartbeat rate[2].AMIO is a multichannel antagonist.SOF and its analogue MNI-1 have been reported to enhance the inhibitory effect of AMIO on calcium ions in cardiomyocytes and may inhibit L-type Cav channels,but the molecular mechanism remains unclear[3,4].
