重组人干扰素α-2b凝胶在慢性宫颈炎合并高危型HPV感染治疗中的临床效果评价

Clinical evaluation of recombinant human interferon α-2b gel in the treatment of chronic cervicitis complicated with high-risk HPV infection

目的分析重组人干扰素α-2b凝胶在慢性宫颈炎合并高危型人乳头瘤病毒(HPV)感染治疗中的临床效果。方法选取60例慢性宫颈炎合并高危型HPV感染患者,并通过随机数字表法进行分组,分别为对照组(30例,常规治疗)、研究组(30例,重组人干扰素α-2b联合常规治疗)。比较两组各项指标。结果两组白带异常、腰酸及下腹坠胀消失时间比较,研究组均短于对照组,差异具有统计学意义(P<0.05)。治疗后与治疗前比,两组血清白细胞介素-6、肿瘤坏死因子-α、超敏C反应蛋白水平均降低,且与对照组比,研究组水平更低,差异具有统计学意义(P<0.05)。两组临床总有效率比较,研究组高于对照组,差异具有统计学意义(P<0.05)。结论在慢性宫颈炎合并高危型HPV感染治疗中,采用重组人干扰素α-2b凝胶能够有效减轻患者炎症反应,促进临床症状改善,取得较好的临床治疗效果。

Objective To analyze the clinical effect of recombinant human interferon α-2b gel in the treatment of chronic cervicitis complicated with high-risk human papillomavirus(HPV) infection. Methods A total of 60 patients with chronic cervicitis complicated with high-risk HPV infection were selected and divided into the control group(25 cases, routine treatment) and the study group(25 cases, recombinant human interferon α-2b combined with routine treatment) by random number table method. The indexes of the two groups were compared. Results The disappearance time of leucorrhea abnormality, lumbar acid and lower abdominal distension were compared between the two groups, and the study group was shorter than the control group, and the differences were statistically significant(P<0.05). After treatment versus before treatment,serum levels of interleukin-6, tumor necrosis factor-α and hypersensitive C-reactive protein decreased in both groups, and compared with the control group, the level of the study group was lower, and the differences were statistically significant(P<0.05). The total clinical effective rate of the two groups was compared,and the study group was higher than the control group, and the difference was statistically significant(P<0.05). Conclusion In the treatment of chronic cervicitis complicated with high-risk HPV infection, recombinant human interferon α-2b gel can effectively reduce the inflammatory response of patients, promote the improvement of clinical symptoms, and achieve clinical therapeutic effect.