NCAPG对乙型肝炎病毒导致肝癌以及预后影响

Effect of NCAPG on the pathogenesis and prognosis of hepatitis B virus causing hepatocellular carcinoma

目的通过乙型肝炎病毒(HBV)相关肝癌和无病因肝癌之间的对比,找到HBV导致肝癌的核心基因以及对预后的影响。方法通过Time、Ualcan发现基因与导致肝癌时的相关浸润细胞等方面的关系。运用Kaplan-Meier进行生存分析,筛选出有关的肝细胞癌临床数据,证明研究基因属于一个独立预后因素。结果共筛选出117个只在HBV导致肝癌患者表达的上调基因,同时发现NCAPG这一关键基因高表达时对肝癌的发生以及预后起着一定的作用。结论上述研究通过生物信息分析确定的核心基因及其相关途径,可以极大地丰富本研究对肝癌的发生以及预防的认识,同时NCAPG有较大的概率成为预防和治疗HBV导致肝细胞癌的治疗靶点。

Objective To find the core genes of HBV causing liver cancer and the impact on prognosis by comparing between HBV-associated liver cancer and cause-free liver cancer.Methods Time and Ualcan were used to detect the relationship between the genes and the infiltrating cells of hepatocellular carcinoma.Survival analysis using Kaplan-Meier was performed to screen out relevant clinical data regarding hepatocellular carcinoma,demonstrating the study gene to be an independent prognostic factor.Results Altogether 117 up-regulated genes expressed only in patients with HBV-induced hepatocellular carcinoma were screened,while NCAPG,a key gene,was found to play a role in the development of hepatocellular carcinoma and its prognosis when highly expressed.Conclusion The core genes and their associated pathways identified by bioinformatic analysis in the above study can greatly enrich our understanding of hepatocarcinogenesis as well as prevention,while NCAPG has a higher probability of becoming a therapeutic target for the prevention and treatment of HBV-caused hepatocellular carcinoma.