摘要
Parkinson's disease(PD)is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra,resulting in clinical symptoms,including bradykinesia,resting tremor,rigidity,and postural instability.The pathophysiological changes in PD are inextricably linked to the subcortical structures.Shape analysis is a method for quantifying the volume or surface morphology of structures using magnetic resonance imaging.In this review,we discuss the recent advances in morphological analysis techniques for studying the subcortical structures in PD in vivo.This approach includes available pipelines for volume and shape analysis,focusing on the morphological features of volume and surface area.
基金
Supported by the Guangdong Basic and Applied Basic Research Foundation,No.2021A1515220131
Youth Exploration Fund of Shenzhen Health Economics Society,No.202211
and Clinical Research Project of Shenzhen Second People’s Hospital,No.223375022.