肠道菌群与肝衰竭微生态调节治疗的研究进展

Advances in research of microbiome regulation as a therapy for liver failure

人体的肠道菌群复杂多样,众多肠道菌群之间形成了结构及组成复杂的肠道微生态系统.研究表明,肠道微生态系统失衡与肝衰竭的发生、发展密切相关,且肠道微生态失衡程度与肝衰竭严重程度有显著相关性.因此,肠道微生态调节在肝衰竭的治疗及改善预后中的重要作用日益凸显.但由于肠道菌群组成及结构的复杂性及其参与肝衰竭发生发展的作用机制尚未十分明确,使其在临床的规范应用受到一定限制,本文就肠道菌群与肝衰竭微生态调节治疗的研究进展进行综述.

The intestinal flora of the human body is complex and diverse, and the structure and composition of the intestinal micro-ecosystem formed by the intestinal flora are complicated. Studies have shown that the imbalance of the intestinal micro-ecosystem is closely related to the occurrence and development of liver failure, and the degree of intestinal microecological imbalance is significantly correlated with the severity of liver failure. Therefore, the role of intestinal microbiome regulation in the treatment of liver failure and the improvement of prognosis has increasingly attracting the attention of scholars. However, due to the complexity of the composition and structure of the intestinal flora and its mechanism of action involved in the development of liver failure, the application of intestinal microbiome regulation in the clinic is limited to a certain extent. In this paper, we review the research progress of microbiome regulation as a therapy for liver failure.