心血管疾病治疗中的中西药药物相互作用

Interaction of Chinese and western medicines in treatment of cardiovascular diseases

心血管疾病是当今社会人类健康面临的重要公共卫生问题,中西医结合是我国心血管疾病防治的主要方式之一。然而中药成分复杂,与心血管治疗药合用过程中可能会与之产生相互影响,进而引发中西药相互作用(herb-drug interaction,HDI)。HDI信息能够为中西药合用在心血管病的临床施治中提供合理依据,有效避免因药物之间的相互影响而引起的临床安全事件的发生。但有关中药相互作用的研究与西药相比十分匮乏,尚未有心血管疾病有关HDI研究内容系统报道。该文首先简介了引发HDI的机制,然后针对心血管病常用药物类型总结和归纳了现有HDI的研究进展,剖析了研究中存在的问题,并从应用、监管以及研究多个角度提出了建议和展望。通过梳理以期促进对临床用药中HDI问题的关注,为心血管疾病治疗中的中西药联用提供合理用药参考。

Cardiovascular diseases are a global public health problem,and the combination of Chinese and western medicine tends to be a major solution in China.However,the complex components in traditional Chinese medicine may interact with the therapeutic western medicines for the diseases,which will lead to the herb-drug interaction(HDI).The information on the interaction can serve as a reference for the rational combination of the Chinese and western medicines in the clinical treatment of cardiovascular diseases and help avoid the occurrence of clinical safety events.However,the research on the interaction of Chinese medicine is limited as compared with that on western medicine,and no systematic review on HDI in the treatment of cardiovascular diseases is available.Therefore,this study first introduced the mechanism of HDI,then summarized the research on HDI for the commonly used drugs for cardiovascular diseases,analyzed the problems in the available studies,and put forward suggestions on the application,regulation,and research.This study aims to highlight HDI in clinical drug use and provide a reference for rational use of combination of Chinese and western medicines in the treatment of cardiovascular diseases.