期刊文献+

2型糖尿病肾病患者血糖波动与肾功能和氧化应激的相关性分析 被引量:1

Correlations of blood glucose fluctuation with renal function and oxidative stress in patients with type 2 diabetes nephropathy
下载PDF
导出
摘要 目的探讨2型糖尿病肾病患者血糖波动与肾功能和氧化应激的相关性分析。方法选取2019年1月至2022年1月济南市第二人民医院收治的2型糖尿病患者82例,其中单纯2型糖尿病28例(单纯2型糖尿病组)、2型糖尿病肾病54例(2型糖尿病肾病组),另选取17例健康者为健康组。单纯2型糖尿病组患者中,男14例,女14例,年龄31~68(49.52±8.52)岁,吸烟5例;2型糖尿病肾病组患者中,男33例,女21例,年龄30~70(50.52±8.61)岁,吸烟3例;健康组中男10例,女7例,年龄30~80(52.52±8.77)岁,吸烟3例;收集研究对象的临床资料,比较3组研究对象的血糖波动指标(24 h平均血糖标准差、平均血糖波动幅度),采用全自动生化分析仪测定肾功能尿素氮(BUN)、肌酐(SCr),比较3组患者氧化应激活性氧(ROS)、超氧化物歧化酶(SOD)水平。采用t、χ^(2)检验和单因素方差分析,采用Pearson法分析2型糖尿病肾病患者血糖波动与肾功能和氧化应激的相关性。结果与健康组相比,单纯2型糖尿病组、2型糖尿病肾病组患者24 h平均血糖标准差、平均血糖波动幅较高(F=26.446、49.198,均P<0.001),2型糖尿病肾病组高于单纯2型糖尿病组,两组比较差异有统计学意义(均P<0.05)。与健康组相比,单纯2型糖尿病组、2型糖尿病肾病组患者BUN、SCr较低(F=17.541、16.524,均P<0.001),2型糖尿病肾病组低于单纯2型糖尿病组(均P<0.05)。与健康组相比,单纯2型糖尿病组、2型糖尿病肾病组患者ROS、SOD较低(F=21.250、18.522,均P<0.001),2型糖尿病肾病组低于单纯2型糖尿病组(均P<0.05)。Pearson结果显示,BUN、SCr、ROS、SOD与2型糖尿病肾病平均血糖波动幅度呈负相关(r=-0.365、-0.687、-0.854、-0.257,P=0.012、0.021、0.015、0.010)。结论2型糖尿病肾病患者血糖波动与肾功能和氧化应激呈现负相关。 Objective To explore the correlations of blood glucose fluctuation with renal function and oxidative stress in patients with type 2 diabetes nephropathy.Methods Eighty-two patients with type 2 diabetes treated at Jinan Second People's Hospital from January 2019 to January 2022 were divided into a simple type 2 diabetes group(28 cases)and a type 2 diabetes nephropathy group(54 cases);17 healthy people were selected as a healthy group.The clinical data were collected and compared.In the simple type 2 diabetes group,there were 14 males and 14 females who were 31-68(49.52±8.52)years old,with 5 smokers.In type 2 diabetes nephropathy group,there were 33 males and 21 females who were 30-70(50.52±8.61)years old,with 3 smokers.In the healthy group,there were 10 males and 7 females who were 30-80(52.52±8.77)years old,with 3 smokers.The 24 h mean blood glucose standard deviations and mean blood glucose fluctuation ranges of the three groups were compared.The blood urea nitrogen(BUN)and creatinine(SCr)were measured by the automatic biochemical analyzer.The levels of reactive oxygen species(ROS)and superoxide dismutase(SOD)of the three groups were compared.t andχ^(2)tests and one-way ANOVA were applied.The Pearson method was used to analyze the correlations of blood glucose fluctuation with renal function and oxidative stress in the patients with type 2 diabetes nephropathy.Results The 24 h mean blood glucose standard deviations and the mean blood glucose fluctuation ranges in the simple type 2 diabetes group and the type 2 diabetes nephropathy group were higher those in the healthy group(F=26.446 and,49.198,both P<0.001),and those in the type 2 diabetes nephropathy group were higher than those in the simple type 2 diabetes group,with statistical significance(both P<0.05).The BUN and SCR in the simple type 2 diabetes group and the type 2 diabetes nephropathy group were lower than those in the healthy group(F=17.541 and 16.524,both P<0.001),and those in the type 2 diabetes nephropathy group were lower than those in the simple type 2 diabetes group(both P<0.05).The ROS and SOD in the simple type 2 diabetes group and the type 2 diabetes nephropathy group were lower than those in the healthy group(F=21.250 and 18.522,both P<0.001),and the levels in the type 2 diabetes nephropathy group were lower than those in the simple type 2 diabetes group(both P<0.05).Pearson's results showed that BUN,SCR,ROS,and SOD were negatively correlated with the mean blood glucose fluctuation of the patients with type 2 diabetes nephropathy(r=-0.365,-0.687,-0.854,and-0.257;P=0.012,0.021,0.015,and 0.010).Conclusion There are negative correlations of blood glucose fluctuation with renal function and oxidative stress in patients with type 2 diabetes nephropathy.
作者 张娜 刘梅 嵇高德 杨明 鞠瀚 Zhang Na;Liu Mei;Ji Gaode;Yang Ming;Ju Han(Department of Internal Medicine,Jinan Second People's Hospital,Jinan 250000,China;Physical Examination Center,Jinan Second People's Hospital,Jinan 250000,China)
出处 《国际医药卫生导报》 2022年第23期3296-3300,共5页 International Medicine and Health Guidance News
基金 山东省医药卫生科技发展计划项目(202107020517)。
关键词 2型糖尿病 肾功能 尿素氮 肌酐 氧化应激 活性氧 超氧化物歧化酶 Type 2 diabetes nephropathy Renal function Blood urea nitrogen Creatinine Oxidative stress Reactive oxygen species Superoxide dismutase
  • 相关文献

参考文献3

二级参考文献40

  • 1陈莹,陈青云.糖尿病运动疗法的研究进展与现实问题[J].中国组织工程研究与临床康复,2007,11(30):6039-6042. 被引量:43
  • 2Yang W,Lu J,Weng J,et al. Prevalence of diabetes among men and women in China. N Engl J Med,2010,362:1090-1101.
  • 3Mehri S, Koubaa N, Hammami S, et al. Genotypic interactions of renin-angiotensinsystem genes with diabetes type 2 in a Tu- nisian population. Life Sci, 2010,7 : 49-54.
  • 4Shah VN,Cheema BS,Sharma R,et al. ACAC 13 gene (rs2268388) and AGTP,1 gene (rs5186) polymorphism and the risk of nephrop- athy in Asian Indian patients with type 2 diabetes. Mol Cell Bio- chem, 2013,372:191-198.
  • 5Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for theyear 2000 and projections for 2030. Diabetes Care, 2004,7: 1047-1053.
  • 6Ahluwalia TS, Lindholm E,Groop LC. Common variants in CNDP1 and CNDP2,and risk of nephropathy in type 2 diabetes. INabetolo- gia, 2011,54: 2295-2302.
  • 7Chakkera HA, Hanson RL, Kobes S, et al. Association of vari ants in the camosine peptidase 1 gene (CNI)P1) with diabetic nephropathy in American Indians. Mol Genet Metab, 2011,3: 185-190.
  • 8张京慧,唐四元,杨丽,马静,屈茜.运动干预对2型糖尿病患者生活质量的影响[J].中华行为医学与脑科学杂志,2009,18(1):46-48. 被引量:2
  • 9徐划萍,陆大江.2型糖尿病患者有氧踏车运动干预的疗效[J].中国老年学杂志,2011,31(11):1982-1983. 被引量:23
  • 10朱海清,杨文英.亚洲人群糖尿病患病情况:现状和未来[J].中华流行病学杂志,2011,32(11):1065-1067. 被引量:18

共引文献7

同被引文献14

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部