摘要
环磷酸腺苷(cyclic adenosine monophosphate,cAMP)是调节细胞信号转导的“第二信使”。腺苷酸环化酶(adenylyl cyclases,ACs)和磷酸二酯酶(phosphodiesterases,PDEs)能够在细胞内直接调节cAMP水平,进而调控下游信号通路。通过提高细胞内cAMP水平可抑制炎症、增强平滑肌松弛,是防治慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的有效策略。该文对调控cAMP的信号通路及其在防治COPD中的作用机制和相关药物进行了简要综述,以期为进一步研究和开发调控cAMP用于防治COPD的新靶点药物提供参考。
Cyclic adenosine monophosphate(cAMP)is a“second messenger”that regulates cell signal transduction.Adenylyl cyclases(ACs)and phosphodiesterases(PDEs)can directly regulate cAMP level in cells and then regulate the downstream signaling pathways.Increasing intracellular cAMP level can inhibit inflammation and enhance smooth muscle relaxation,which is an effective strategy for the prevention and treatment of chronic obstructive pulmonary disease(COPD).This paper briefly summarizes the signaling pathways regulating cAMP and their mechanisms and related drugs in COPD therapy,hoping to provide references for further research and development of new target drugs which regulate cAMP for the prevention and treatment of COPD.
作者
梁亚萍
王略力
黄蓉
方雁
杜晓华
陈晨
肖创
杨为民
LIANG Ya-ping;WANG Lue-li;HUANG Rong;FANG Yan;DU Xiao-hua;CHEN Chen;XIAO Chuang;YANG Wei-min(School of Pharmaceutical Science&Yunnan Key Lab of Pharmacology for Natural Products,Kunming 650500,China;First Affiliated Hospital of Kunming Medical University,Kunming Medical University,Kunming 650031,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2022年第12期1773-1777,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81870037)
云南省科技厅项目(No 202005AF150043,202005AE160004,2019FD 020)。
关键词
环磷酸腺苷
慢性阻塞性肺疾病
腺苷酸环化酶
磷酸二酯酶
蛋白激酶A
药物研发
cyclic adenosine monophosphate
chronic obstructive pulmonary disease
adenylyl cyclase
phosphodiesterase
protein kinase A
drug development
