化疗诱导的肿瘤细胞应激衰老——“是利还是弊?”

Stress-induced senescence of tumor cells by chemotherapy,good or bad?

传统观点认为,化疗诱导的肿瘤细胞应激衰老有利于遏制肿瘤增长和进展,对抗癌治疗有积极效应。但随着长期以来对化疗抗肿瘤效果真实世界的观察和研究,发现化疗后或复发时,肿瘤细胞往往表现出更强的增殖能力和侵袭性,肿瘤复发和难治愈成为越来越关注的突出问题。因此,有必要重新思考和深挖化疗诱导肿瘤细胞应激衰老的真实过程和潜能。该文从化疗诱导应激衰老的角度,查阅相关文献和研究最新进展,主要分析、讨论应激衰老在抗癌过程中的潜在负面效应和临床意义,进一步全面认识化疗抗肿瘤的“利弊”双重功能,期望为改良传统化疗方案、研发抗肿瘤新药、走出目前化疗抗癌的困境、提供一些新的思路和理论依据。

Traditionally it is believed that stress-induced senescence of tumor cells induced by chemotherapy is beneficial to inhibit tumor growth and progression,and has a positive effect on anti-tumor.However,with the longtime observation and clinical study on the anti-tumor effect of chemotherapy in the real world,it is found that tumor cells often show stronger proliferation and invasiveness after chemotherapy or relapse,tumor recurrence and refractoriness become very hot and tricky issues.So,it is necessary to rethink and explore the real process and potential effect of stress-induced senescence by chemotherapy.Here from the perspective of stress-induced senescence of tumor cells by chemotherapy,this study mainly analyzes and discusses the potential negative effects and clinical significance,so as to fully understand its pros and cons in the anti-tumor effect,hoping to provide some new ideas and rationale for improving traditional tumor chemotherapy,developing new anti-tumor drugs and coming out of the current dilemma of chemotherapy.