益脾养肝法联合TACE对原发性肝癌患者肝功能及巨噬细胞介导细胞因子水平的影响

Effects of benefiting spleen and nourishing liver method combined with TACE on liver function and macrophage-mediated cytokine levels in patients with primary liver cancer

目的 观察益脾养肝法联合肝动脉化疗栓塞术(TACE)对原发性肝癌患者肝功能及巨噬细胞介导细胞因子水平的影响。方法 将我院60例原发性肝癌患者随机分成对照组与治疗组各30例。对照组采用TACE治疗,治疗组采用益脾养肝法+TACE治疗。比较两组治疗后总缓解率,肝功能[总胆红素(Tbil)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)],肿瘤标志物水平[甲胎蛋白(AFP)、癌胚抗原(CEA)],巨噬细胞介导细胞因子水平[血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(FGF)、白细胞介素(IL-13、IL-4、IL-10)、转化生长因子(TGF-β)]。结果 治疗后,治疗组总缓解率显著高于对照组(P<0.05);两组Tbil、ALT、AST水平均降低,治疗组Tbil、ALT、AST水平均低于对照组(P<0.05);两组AFP、CEA水平均降低,治疗组AFP、CEA水平均低于对照组(P<0.05);两组VEGF、FGF、IL-13、IL-4、IL-10、TGF-水平均降低,治疗组VEGF、FGF、IL-13、IL-4、IL-10、TGF-β水平均低于对照组(P<0.05)。结论 益脾养肝法+TACE能提高原发性肝癌患者疗效,改善肝功能,降低肿瘤标志物水平,下调巨噬细胞介导细胞因子水平。

Objective To observe the effect of benefiting spleen and nourishing liver method combined with transcatheter arterial chemoembolization(TACE)on liver function and macrophage-mediated cytokine levels in patients with primary liver cancer. Methods Sixty patients with primary liver cancer were randomly divided into control group and treatment group,30cases in each group. Control group was treated with TACE,and treatment group was treated with benefiting spleen and nourishing liver method on the basis of control group. After treatment,the total remission rate,liver function [total bilirubin(Tbil),alanine aminotransferase(ALT),aspartate aminotransferase(AST)],tumor marker levels [alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA)],macrophage-mediated cytokine levels [vascular endothelial growth factor(VEGF),basic fibroblast growth factor(FGF),interleukins(IL-13,IL-4,IL-10),transforming growth factor(TGF-β)] were compared between the two groups.Results After treatment,the total remission rate in treatment group was significantly higher than in control group( P<0.05);Tbil,ALT and AST levels were decreased in both groups,and were lower in treatment group than in control group( P<0.05);AFP and CEA levels were decreased in both groups,and were lower in treatment group than in control group(P <0.05);VEGF,FGF,IL-13,IL-4,IL-10,and TGF-β levels were decreased in both groups,and were lower in treatment group than in control group( <0.05). Conclusion Benefiting spleen and nourishing liver method combined with TACE can improve the curative effect of patients with primary liver cancer,improved liver function,reduced the level of tumor markers,and down-regulated the level of macrophage-mediated cytokines.