11种运动对老年肌少症患者身体功能改善效果的网状Meta分析

The improvement effect of 11 kinds of exercise protocols on elderly patients with sarcopenia:a network Meta analysis

目的通过网状Meta分析评价11种运动训练对老年肌少症患者身体功能、肌肉力量和肌肉质量改善效果的影响。方法检索Web of Science、PubMed、Embase、Cochrane Library、CINAHL、中国知网、中国生物医学文献数据库、万方数据库和维普数据库中关于运动训练对老年肌少症患者身体功能、肌肉力量和肌肉质量改善效果的随机对照试验。检索时限为建库至2022年1月。采用Stata 15.0软件进行网状Meta分析。结果纳入34项研究,共2199例患者。网状Meta分析结果表明,与非运动对照组相比,阻力训练、小组综合训练、八段锦、全身振动训练、家庭综合训练可改善老年肌少症患者的身体功能(P<0.05);阻力训练和壶铃训练可改善老年肌少症患者的握力(P<0.05);阻力训练可改善老年肌少症患者的骨骼肌指数(P<0.05)。结论在改善老年肌少症患者身体功能、肌肉力量和质量方面,阻力训练是目前最优的运动干预措施,其次为小组综合训练和全身振动训练,但仍需更多研究进一步论证。

Objective To evaluate the effect of 11 kinds of exercise training on the improvement of physical function,muscle strength,and muscle mass in elderly patients with sarcopenia by network Meta-analysis.Methods A systematic search of Web of Science,PubMed,Embase,Cochrane Library,CINAHL,CNKI,Chinese Biomedical Literature Database(CBM),WanFang and VIP was carried out to identify randomized control trials about the effect of exercise training on the improvement of elderly patients with sarcopenia from inception to January 2022.The network meta-analysis was performed by Stata 15.0 software.Results A total of 34 pieces of research involving 2199 patients and 11 exercise training were included.The results of network meta-analysis indicated that resistance training,Baduanjin,whole body vibration training,group comprehensive training,and home comprehensive training could improve the physical function of elderly patients with sarcopenia compared with non-exercise controls(P<0.05);resistance training and kettlebell training could significantly improve the grip strength of elderly patients with sarcopenia(P<0.05);resistance training could improve the skeletal muscle index of elderly patients with sarcopenia(P<0.05).Conclusion This study showed that resistance training is currently the best exercise intervention in elderly patients with sarcopenia,followed by group comprehensive training and whole body vibration training.However,more studies are still needed to further demonstrate.