基于单分子阵列技术的阿尔茨海默病血液神经标志物的研究进展

Research progress on single-molecule array technology-based blood neuronal markers for Alzheimer's disease

早发现、早干预是防治阿尔茨海默病的重要策略。阿尔茨海默病的血液筛查具有费用低、操作方便快捷等优势,但也存在着外周血中标志物含量低、检测方法灵敏度不足等问题。目前,灵敏的蛋白分子检测技术-单分子阵列(Simoa)技术可对传统方法无法检测到的低浓度生物标志物进行准确分析。本文就应用单分子阵列这一新兴技术进行阿尔茨海默病早期诊断相关的血液神经标志物检测的研究进展作一综述。

Early detection and intervention is an important strategy for the prevention and treatment of Alzheimer's disease(AD).Blood screening for AD has advantages such as low cost and convenient sample collection.However,there are also problems such as low levels of markers in peripheral blood and insufficient sensitivity of detection methods.At present,as a highly sensitive detection technology for protein molecules,single-molecule array(Simoa)technology can accurately analyze low-concentration biomarkers that cannot be detected by traditional methods.This article reviews research progress on blood neuronal markers for early AD diagnosis based on the new Simoa technology.