慢性胰腺炎相关骨病发生风险的研究进展

Research progress on the risk of osteopathy complicated by chronic pancreatitis

慢性胰腺炎(chronic pancreatitis,CP)可造成胰腺不可逆的形态学改变,通常会引起永久性功能丧失。流行病学研究发现,CP患者骨病(包括骨质减少和骨质疏松症)患病率高,显著增加骨折风险。目前,CP相关骨病确切的发病机制尚不清楚,但研究发现CP患者存在多种导致骨质减少的风险因素,包括胰腺外分泌功能不全、脂溶性维生素缺乏、低体重指数、慢性炎症、吸烟、喝酒、性腺机能减退和阿片类药物使用等。围绕这些风险因素开展基本的预防措施,是CP相关骨病防治的重要环节。该文就CP相关骨病的流行病学、风险因素和防治建议作一综述。

Chronic pancreatitis(CP)causes irreversible morphological changes in the pancreas,usually resulting in permanent loss of function.The epidemiology studies have found that patients with CP have a high prevalence of osteopathy(including osteopenia and osteoporosis),which significantly increases the risk of fracture.At present,the exact pathogenesis of osteopathy complicated by chronic pancreatitis is still unclear.Studies have identified multiple risk factors that promote bone loss in patients with CP,including exocrine pancreatic insufficiency,fat-soluble vitamin deficiency,low body mass index,chronic inflammation,long-term use of tobacco and alcohol,hypogonadism and opioid use.Basic preventive measures around these risk factors are an important part of the prevention and treatment of osteopathy complicated by chronic pancreatitis.This article reviews the epidemiology,risk factors and prevention advice of osteopathy complicated by chronic pancreatitis.