川崎病合并巨大冠状动脉瘤的临床研究进展

Advances in Kawasaki disease combined with giant coronary aneurysm

川崎病冠状动脉病变已成为部分国家、地区常见的儿童获得性心血管疾病之一,巨大冠状动脉瘤是川崎病冠状动脉病变中的严重类型,后期完全恢复的可能性较小,其心血管事件发生率和病死率均明显升高。巨大冠状动脉瘤患儿进入成年期后有较高的心血管疾病发病风险,而且儿童期巨大动脉瘤与青壮年心源性猝死及成年后冠状动脉粥样硬化的发生密切相关,对患儿的长期预后和生活质量产生严重影响。该文就川崎病合并巨大冠状动脉瘤的临床特点及预后作一综述。

Kawasaki disease coronary artery lesions have become one of the common acquired cardiovascular diseases in children in some countries and regions.Giant coronary artery aneurysms are a severe type of Kawasaki disease coronary artery lesion with less likelihood of complete recovery at a later stage,and their cardiovascular event rate and mortality are significantly higher than those of other children with Kawasaki disease.Children with giant coronary aneurysms are at higher risk of cardiovascular disease in adulthood and are closely associated with sudden cardiac death in young adulthood and the development of coronary atherosclerosis in adulthood,with serious implications for the long-term prognosis and quality of life of the child.This article reviews the clinical features and prognosis of Kawasaki disease combined with giant coronary aneurysms.